ROSIGLITAZONE INHIBITS HMC-1 CELL MIGRATION AND ADHESION THROUGH A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA-DEPENDENT MECHANISM

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ZHANG GUQIN; YANG JIONG; LI PING; CAO JIE; NIE HANXIANG

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2014 | Volume:13 | Issue:1 Page(s): 11-18

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Title

ROSIGLITAZONE INHIBITS HMC-1 CELL MIGRATION AND ADHESION THROUGH A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA-DEPENDENT MECHANISM

Author(s)

Keywords

ADHESION

MAST CELLS

MIGRATION

PPARγ

ROSIGLITAZONE

Abstract

Mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. Peroxisome proliferator-activated receptor gamma (PPARg) is a member of the large nuclear hormone receptor transcription factor superfamily, and has been recently implicated in the anti-inflammatory response.To investigate a possible role for PPARg in human MAST CELLS, we studied the effects of a PPARg ligand, ROSIGLITAZONE (RG), on stem cell factor (SCF) -induced MIGRATION and fibronectin-induced ADHESION in human mast cell-1 (HMC-1) cells.It was found that HMC-1 cells expressed PPARg mRNA. RG inhibited SCF-induced HMC-1 cell MIGRATION and fibronectin-induced HMC-1 cell ADHESION, the selective PPARgantagonist GW9662 prevented the inhibitory effect of RG on HMC-1 cells.In conclusion, RG inhibits the MIGRATION and ADHESION of HMC-1 cells by a PPARg-dependent mechanism.

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APA: Copy

ZHANG, GUQIN, YANG, JIONG, LI, PING, CAO, JIE, & NIE, HANXIANG. (2014). ROSIGLITAZONE INHIBITS HMC-1 CELL MIGRATION AND ADHESION THROUGH A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA-DEPENDENT MECHANISM. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 13(1), 11-18. SID. https://sid.ir/paper/291381/en

Vancouver: Copy

ZHANG GUQIN, YANG JIONG, LI PING, CAO JIE, NIE HANXIANG. ROSIGLITAZONE INHIBITS HMC-1 CELL MIGRATION AND ADHESION THROUGH A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA-DEPENDENT MECHANISM. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2014;13(1):11-18. Available from: https://sid.ir/paper/291381/en

IEEE: Copy

GUQIN ZHANG, JIONG YANG, PING LI, JIE CAO, and HANXIANG NIE, “ROSIGLITAZONE INHIBITS HMC-1 CELL MIGRATION AND ADHESION THROUGH A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA-DEPENDENT MECHANISM,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 13, no. 1, pp. 11–18, 2014, [Online]. Available: https://sid.ir/paper/291381/en

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