INTERLEUKIN-25 ENHANCES ALLERGIC INFLAMMATION THROUGH P38MAPK AND NF-KB PATHWAYS IN MOUSE MODELS OF ALLERGIC RHINITIS

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LI ZHIPENG; WANG HUI; LIU LISI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2014 | Volume:13 | Issue:6 Page(s): 412-419

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Information Journal Paper

Title

INTERLEUKIN-25 ENHANCES ALLERGIC INFLAMMATION THROUGH P38MAPK AND NF-KB PATHWAYS IN MOUSE MODELS OF ALLERGIC RHINITIS

Author(s)

LI ZHIPENG | WANG HUI | LIU LISI | Issue Writer Certificate

Keywords

ALLERGIC RHINITIS

INTERLEUKIN-25

MICE

NF-KAPPA B

P38 MITOGEN-ACTIVATED PROTEIN KINASES

Abstract

Interleukin (IL) -25, a cytokine of IL-17 family, can activate P38 MITOGEN-ACTIVATED PROTEIN KINASES (MAPK) and Nuclear Factor (NF) -c B pathways to propagate Th2 responses.The ALLERGIC RHINITIS mouse model was established by stimulating BALB/c mouse with ovalbumin (OVA). Then we detected expression of IL-25 and downstream p38MAPK and NF-cB.The expression of IL-25, p38MAPK and NF-cB were detected in the OVA-induced ALLERGIC RHINITIS mouse model. The allergic parameters, such as allergic symptoms, serum OVA-specific immunoglobulin E (IgE) levels and eosinophil infiltration in the nasal mucosa were compared between OVA group and control group.OVA-induced MICE displayed significantly higher allergic responses compared with the saline control group. OVA induced MICE demonstrated more allergic symptoms, higher serum OVA-specific IgE levels and eosinophil infiltrations. The increased expression of IL-25, p38MAPK and NF-cB immunoreactivity were detected in epidermal cells in the OVA group. The mRNA measurement of IL-25, p38MAPK and NF-cB showed the same result.IL-25 enhances the OVA-induced ALLERGIC RHINITIS by activating p38MAPK and NF-cB pathways.

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APA: Copy

LI, ZHIPENG, WANG, HUI, & LIU, LISI. (2014). INTERLEUKIN-25 ENHANCES ALLERGIC INFLAMMATION THROUGH P38MAPK AND NF-KB PATHWAYS IN MOUSE MODELS OF ALLERGIC RHINITIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 13(6), 412-419. SID. https://sid.ir/paper/291386/en

Vancouver: Copy

LI ZHIPENG, WANG HUI, LIU LISI. INTERLEUKIN-25 ENHANCES ALLERGIC INFLAMMATION THROUGH P38MAPK AND NF-KB PATHWAYS IN MOUSE MODELS OF ALLERGIC RHINITIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2014;13(6):412-419. Available from: https://sid.ir/paper/291386/en

IEEE: Copy

ZHIPENG LI, HUI WANG, and LISI LIU, “INTERLEUKIN-25 ENHANCES ALLERGIC INFLAMMATION THROUGH P38MAPK AND NF-KB PATHWAYS IN MOUSE MODELS OF ALLERGIC RHINITIS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 13, no. 6, pp. 412–419, 2014, [Online]. Available: https://sid.ir/paper/291386/en

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