ASSOCIATION BETWEEN CYTOKINE PRODUCTION AND DISEASE SEVERITY IN ALZHEIMER’S DISEASE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JABBARI AZAD FARAHZAD; TALAEI ALI; RAFATPANAH HOUSHANG; YOUSEFZADEH HADIS; JAFARI RAHELEH; JAFARI MAJID; TALAEI ANDISHEH; FARID HOSSEINI REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2014 | Volume:13 | Issue:6 Page(s): 433-439

Download Full-Text

View:

354

Download:

122

Cites:

Information Journal Paper

Title

ASSOCIATION BETWEEN CYTOKINE PRODUCTION AND DISEASE SEVERITY IN ALZHEIMER’S DISEASE

Author(s)

Keywords

ALZHEIMER’S DISEASE (AD)

CYTOKINE

VITAMIN B12

Abstract

The role of transforming growth factor (TGF) b1, interferon (IFN) -g, interleukin (IL) -2, IL-3, and IL-6 in the pathogenesis of Alzheimer’s Disease (AD) has long been reported in literature. In this case-control study, the concentrations of these CYTOKINEs in altered T lymphocytes, as well as serum VITAMIN B12, have been compared in terms of factors such as, age, the clinical course and the patients’ disease risk.40 patients who met the DSM-IV-TR criteria of AD were selected and an age- and gendermatched control group was recruited. The participants’ cognitive performance was measured according to the Mini Mental State Examination (MMSE), the Global Deterioration Scale (GDS) and Clinical Dementia Ratio (CDR). The levels of CYTOKINEs were measured in supernatants of lymphocytes culture, using assays of ELISA and atomic absorption.Higher levels of IL-6 and IFN-g were found more in the altered T lymphocytes of the AD patients rather than in the control individuals. Furthermore, a marginal significant difference was found between the TGF-b levels of the two study groups. Regression analysis of CDR score and CYTOKINEs showed the inverse significant correlation between CDR score and IFN-g levels. Furthermore, the relation between MMSE scores and IFN-g was significant, meaning that by increasing MMSE score, IFN-g level was significantly increased.This study suggests that the levels of IL-6 and IFN-g are significantly increased in altered T lymphocytes of AD patients, as compared to those who are not inflicted with AD, and that they are related to the patient’s age. Also, IFN-g is related to the severity stage of the AD.

Cites

No record.

References

No record.

Cite

APA: Copy

JABBARI AZAD, FARAHZAD, TALAEI, ALI, RAFATPANAH, HOUSHANG, YOUSEFZADEH, HADIS, JAFARI, RAHELEH, JAFARI, MAJID, TALAEI, ANDISHEH, & FARID HOSSEINI, REZA. (2014). ASSOCIATION BETWEEN CYTOKINE PRODUCTION AND DISEASE SEVERITY IN ALZHEIMER’S DISEASE. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 13(6), 433-439. SID. https://sid.ir/paper/291390/en

Vancouver: Copy

JABBARI AZAD FARAHZAD, TALAEI ALI, RAFATPANAH HOUSHANG, YOUSEFZADEH HADIS, JAFARI RAHELEH, JAFARI MAJID, TALAEI ANDISHEH, FARID HOSSEINI REZA. ASSOCIATION BETWEEN CYTOKINE PRODUCTION AND DISEASE SEVERITY IN ALZHEIMER’S DISEASE. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2014;13(6):433-439. Available from: https://sid.ir/paper/291390/en

IEEE: Copy

FARAHZAD JABBARI AZAD, ALI TALAEI, HOUSHANG RAFATPANAH, HADIS YOUSEFZADEH, RAHELEH JAFARI, MAJID JAFARI, ANDISHEH TALAEI, and REZA FARID HOSSEINI, “ASSOCIATION BETWEEN CYTOKINE PRODUCTION AND DISEASE SEVERITY IN ALZHEIMER’S DISEASE,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 13, no. 6, pp. 433–439, 2014, [Online]. Available: https://sid.ir/paper/291390/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops