DOWN-REGULATION OF TLR2, 3, 9 AND SIGNALING MEDIATORS, MYD88 AND TRIF, GENE TRANSCRIPT LEVELS IN PATIENTS WITH KAWASAKI DISEASE TREATED WITH IVIG

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MORTAZAVI SEYED HAMID REZA; AMIN REZA; ALYASIN SOHEILA; KASHEF SARA; KARIMI MOHAMMAD HOSEIN; BABAYI MARYAM; YOUNESI VAHID

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2015 | Volume:14 | Issue:2 Page(s): 188-197

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Title

DOWN-REGULATION OF TLR2, 3, 9 AND SIGNALING MEDIATORS, MYD88 AND TRIF, GENE TRANSCRIPT LEVELS IN PATIENTS WITH KAWASAKI DISEASE TREATED WITH IVIG

Author(s)

Keywords

IVIG

KAWASAKI DISEASE

MYD88

TOLL LIKE RECEPTORS

TRIF

Abstract

Kawasaki disease (KD) is an acute febrile systemic vasculitis of childhood characterized by elevated levels of inflammatory mediators at the acute stage. High-dose intravenous immunoglobulin (IVIG) is well accepted as a conventional therapy for KD. The aim of the present study was to determine the expression level of TOLL LIKE RECEPTORS (TLRs) and their corresponding signaling mediators in PBMCs of IVIG-treated KD patients.TLR2, 3, 9 and signaling mediators, MYD88 and TRIF transcript levels were determined in PBMCs from 31 KD patients, before (acute phase), 2 weeks later (sub-acute phase) and 6 weeks later (convalescent phase) of IVIG therapy using real time PCR. The mean age of the patients was 3.6 years and 65% of subjects were male and 35% were female. 20 age-matched irrelevant febrile patients and 20 healthy subjects were included as control groups.Elevated levels of TLR2, MYD88, and TRIF gene transcripts were observed in the PBMCs at acute phase of untreated KD patients in compression with normal subjects. IVIG therapy resulted in significant decrease in TLR2, 3 and 9 (60-90%) as well as MYD88 and TRIF (60-70%) transcripts following 2 and 6 weeks.With Regard to significant up-regulation of MYD88 and TRIF at the acute phase of KD, our findings suggest TLR signaling pathway potential in KD pathogenesis and may also support the assumption of an infectious background in KD. Down-regulation of TLR members and corresponding mediators in IVIG treated patient suggest general TLR pathway suppression as a novel anti-inflammatory mechanism of IVIG.

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APA: Copy

MORTAZAVI, SEYED HAMID REZA, AMIN, REZA, ALYASIN, SOHEILA, KASHEF, SARA, KARIMI, MOHAMMAD HOSEIN, BABAYI, MARYAM, & YOUNESI, VAHID. (2015). DOWN-REGULATION OF TLR2, 3, 9 AND SIGNALING MEDIATORS, MYD88 AND TRIF, GENE TRANSCRIPT LEVELS IN PATIENTS WITH KAWASAKI DISEASE TREATED WITH IVIG. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(2), 188-197. SID. https://sid.ir/paper/291428/en

Vancouver: Copy

MORTAZAVI SEYED HAMID REZA, AMIN REZA, ALYASIN SOHEILA, KASHEF SARA, KARIMI MOHAMMAD HOSEIN, BABAYI MARYAM, YOUNESI VAHID. DOWN-REGULATION OF TLR2, 3, 9 AND SIGNALING MEDIATORS, MYD88 AND TRIF, GENE TRANSCRIPT LEVELS IN PATIENTS WITH KAWASAKI DISEASE TREATED WITH IVIG. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(2):188-197. Available from: https://sid.ir/paper/291428/en

IEEE: Copy

SEYED HAMID REZA MORTAZAVI, REZA AMIN, SOHEILA ALYASIN, SARA KASHEF, MOHAMMAD HOSEIN KARIMI, MARYAM BABAYI, and VAHID YOUNESI, “DOWN-REGULATION OF TLR2, 3, 9 AND SIGNALING MEDIATORS, MYD88 AND TRIF, GENE TRANSCRIPT LEVELS IN PATIENTS WITH KAWASAKI DISEASE TREATED WITH IVIG,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 2, pp. 188–197, 2015, [Online]. Available: https://sid.ir/paper/291428/en

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