PLASMA ADIPONECTIN CONCENTRATIONS AND ADIPONECTIN GENE POLYMORPHISMS ARE ASSOCIATED WITH BRONCHIAL ASTHMA IN THE CHINESE LI POPULATION

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DING YIPENG; YANG HUA; HE HAIWU; SHI HUIFANG; HE PING; YAN SHOUCHUN; JIN TIANBO

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2015 | Volume:14 | Issue:3 Page(s): 292-297

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Title

PLASMA ADIPONECTIN CONCENTRATIONS AND ADIPONECTIN GENE POLYMORPHISMS ARE ASSOCIATED WITH BRONCHIAL ASTHMA IN THE CHINESE LI POPULATION

Author(s)

Keywords

ADIPONECTIN

ASTHMA

CASE-CONTROL STUDIES

Abstract

The purpose of this study was to determine the clinical significance of changes in the plasma ADIPONECTIN concentration in patients with bronchial ASTHMA and to test the association between the single nucleotide polymorphisms (SNPs) rs2241766 and rs1501299 in the ADIPOQ gene and bronchial ASTHMA in the Chinese Li population.We selected 120 cases and 120 controls, and plasma ADIPONECTIN, interleukin (IL)-6, and tumor necrosis factor-alpha (TNF-a) levels were measured by enzyme-linked immunosorbent assay (ELISA). In addition, we genotyped two tag single nucleotide polymorphisms (tSNPs) and evaluated their association with bronchial ASTHMA using the X2 test and genetic model analysis.Compared to controls, patients with acute exacerbation of bronchial ASTHMA showed significantly lower ADIPONECTIN and significantly higher IL-6 and TNF-a levels (p<0.01). A positive association was found between the rs1501299 SNP and acute exacerbation (OR = 1.62; 95% CI= 1.08-2.43; p= 0.019).The inverse correlation between the plasma ADIPONECTIN concentration and ASTHMA exacerbation indicates that ADIPONECTIN may play a protective role in the pathogenesis of ASTHMA. Meanwhile, our findings suggest that ADIPOQ polymorphisms influence the risk of developing bronchial ASTHMA in Chinese Li population.

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APA: Copy

DING, YIPENG, YANG, HUA, HE, HAIWU, SHI, HUIFANG, HE, PING, YAN, SHOUCHUN, & JIN, TIANBO. (2015). PLASMA ADIPONECTIN CONCENTRATIONS AND ADIPONECTIN GENE POLYMORPHISMS ARE ASSOCIATED WITH BRONCHIAL ASTHMA IN THE CHINESE LI POPULATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(3), 292-297. SID. https://sid.ir/paper/291445/en

Vancouver: Copy

DING YIPENG, YANG HUA, HE HAIWU, SHI HUIFANG, HE PING, YAN SHOUCHUN, JIN TIANBO. PLASMA ADIPONECTIN CONCENTRATIONS AND ADIPONECTIN GENE POLYMORPHISMS ARE ASSOCIATED WITH BRONCHIAL ASTHMA IN THE CHINESE LI POPULATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(3):292-297. Available from: https://sid.ir/paper/291445/en

IEEE: Copy

YIPENG DING, HUA YANG, HAIWU HE, HUIFANG SHI, PING HE, SHOUCHUN YAN, and TIANBO JIN, “PLASMA ADIPONECTIN CONCENTRATIONS AND ADIPONECTIN GENE POLYMORPHISMS ARE ASSOCIATED WITH BRONCHIAL ASTHMA IN THE CHINESE LI POPULATION,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 3, pp. 292–297, 2015, [Online]. Available: https://sid.ir/paper/291445/en

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