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Information Journal Paper

Title

EFFECT OF INFLUENZA VIRUS INFECTION IN A MURINE MODEL OF ASTHMA

Pages

  392-401

Abstract

 Respiratory virus infection is a major cause of ASTHMA exacerbation. However, the underlying mechanisms of this exacerbation are unknown. Therefore, to determine the mechanisms, we examined the effect of INFLUENZA infection in a murine model of ASTHMA.Mice were divided into four groups: the phosphate-buffered saline (PBS), house dust mite (HDM), INFLUENZA, and HDM/influenza groups. The INFLUENZA group and the HDM/influenza group were infected with INFLUENZA A virus. We measured airway resistance (Penh value), examined the lung tissue for pathology, and analyzed the cells and CYTOKINEs in bronchoalveolar lavage fluid (BALF) by ELISA.At 50 mg/mL methacholine, the HDM/influenza group showed a significantly higher Penh value than the PBS, HDM, and INFLUENZA groups. The number of NEUTROPHILs in BALF was higher in the HDM/influenza group than in the HDM group. A significantly greater number of lymphocytes and macrophages were detected in the HDM/influenza group than in the HDM group. IFN-g and IL-1b levels were higher in the HDM/influenza group than in the HDM group. IL-5 levels did not vary between the HDM and HDM/influenza groups, IL-10 was significantly lower in the HDM/influenza than in the HDM group. Chemokine (C-X-C motif) ligand 1 (CXCL1) and regulated upon activation, normal T cell expressed and secreted (RANTES) were higher in the HDM/influenza group than in the HDM group.In a murine model of ASTHMA, INFLUENZA-induced airway inflammation appeared to be caused by simultaneous activation of NEUTROPHILic and EOSINOPHILic inflammation.

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    APA: Copy

    KIM, HWAN SOO, LEE, HUISU, KIM, HYUN SOOK, WON, SULMUI, LEE, EU KYOUNG, BANG, KYONGWON, CHUN, YOON HONG, YOON, JONG SEO, KIM, HYUN HEE, & KIM, JIN TACK. (2015). EFFECT OF INFLUENZA VIRUS INFECTION IN A MURINE MODEL OF ASTHMA. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(4), 392-401. SID. https://sid.ir/paper/291466/en

    Vancouver: Copy

    KIM HWAN SOO, LEE HUISU, KIM HYUN SOOK, WON SULMUI, LEE EU KYOUNG, BANG KYONGWON, CHUN YOON HONG, YOON JONG SEO, KIM HYUN HEE, KIM JIN TACK. EFFECT OF INFLUENZA VIRUS INFECTION IN A MURINE MODEL OF ASTHMA. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(4):392-401. Available from: https://sid.ir/paper/291466/en

    IEEE: Copy

    HWAN SOO KIM, HUISU LEE, HYUN SOOK KIM, SULMUI WON, EU KYOUNG LEE, KYONGWON BANG, YOON HONG CHUN, JONG SEO YOON, HYUN HEE KIM, and JIN TACK KIM, “EFFECT OF INFLUENZA VIRUS INFECTION IN A MURINE MODEL OF ASTHMA,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 4, pp. 392–401, 2015, [Online]. Available: https://sid.ir/paper/291466/en

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