POLYMORPHISM IN THE IL-8 GENE PROMOTER AND THE RISK OF ACNE VULGARIS IN A PAKISTANI POPULATION

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HUSSAIN SABIR; IQBAL TAHIR; SADIQ IRFAN; FEROZ SAIMA; SHAFIQUE SATTI HUMAYOON

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2015 | Volume:14 | Issue:4 Page(s): 443-449

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Title

POLYMORPHISM IN THE IL-8 GENE PROMOTER AND THE RISK OF ACNE VULGARIS IN A PAKISTANI POPULATION

Author(s)

Keywords

ASSOCIATION

ACNE VULGARIS

INTERLEUKIN-8

PAKISTAN

POLYMORPHISM

Abstract

Interleukin-8 (IL-8) is a well-known inflammatory chemokine and suggested to be involved in the development of ACNE VULGARIS. This study investigates IL-8 plasma levels in acne patients and healthy controls and the molecular basis for the regulation of the IL-8 gene in a PAKISTANi population. Patients with ACNE VULGARIS (n = 264) and healthy individuals (n = 264) were enrolled in this investigation. Plasma IL-8 levels were determined by enzyme-linked immunosorbent assay (ELISA). The genotyping for IL-8 gene was performed by polymerase chain reaction (PCR) and restriction fragment length POLYMORPHISM (RFLP). Our data showed a statistically significant increase in IL-8 levels from acne patients compared with healthy subjects (154.2 ± 52.1 pg/mL in patients vs. 101.6 ± 33.5 pg/mL in controls, p<0.0001). The IL-8-251T>A (rs4073) POLYMORPHISM was significantly higher in patients with acne compared with the control group (p=0.013). There was a significant difference between the T and A alleles from acne cases and controls (odds ratio OR = 1.6, 95%CI = 1.16-2.19, p = 0.003). Logistic-regression analysis showed that the increased IL-8 levels, and the IL-8-251T>A POLYMORPHISM were significantly associated with acne. Our data suggest that the elevated IL-8 levels and the IL-8-251T>A POLYMORPHISM may be associated with ACNE VULGARIS in the study population.

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APA: Copy

HUSSAIN, SABIR, IQBAL, TAHIR, SADIQ, IRFAN, FEROZ, SAIMA, & SHAFIQUE SATTI, HUMAYOON. (2015). POLYMORPHISM IN THE IL-8 GENE PROMOTER AND THE RISK OF ACNE VULGARIS IN A PAKISTANI POPULATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(4), 443-449. SID. https://sid.ir/paper/291473/en

Vancouver: Copy

HUSSAIN SABIR, IQBAL TAHIR, SADIQ IRFAN, FEROZ SAIMA, SHAFIQUE SATTI HUMAYOON. POLYMORPHISM IN THE IL-8 GENE PROMOTER AND THE RISK OF ACNE VULGARIS IN A PAKISTANI POPULATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(4):443-449. Available from: https://sid.ir/paper/291473/en

IEEE: Copy

SABIR HUSSAIN, TAHIR IQBAL, IRFAN SADIQ, SAIMA FEROZ, and HUMAYOON SHAFIQUE SATTI, “POLYMORPHISM IN THE IL-8 GENE PROMOTER AND THE RISK OF ACNE VULGARIS IN A PAKISTANI POPULATION,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 4, pp. 443–449, 2015, [Online]. Available: https://sid.ir/paper/291473/en

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