Histamine (H1) Receptors, Cyclooxygenase Pathway and Nitric Oxide Formation Involved in Rat Tracheal Smooth Muscle Relaxant Effect of Berberine

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SAADAT SAEIDEH; NAGHDI FARZANEH; Ghorani Vahideh; RAKHSHANDEH HASSAN; BOSKABADY MOHAMMAD HOSSEIN

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2019 | Volume:18 | Issue:3 Page(s): 320-331

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Title

Histamine (H1) Receptors, Cyclooxygenase Pathway and Nitric Oxide Formation Involved in Rat Tracheal Smooth Muscle Relaxant Effect of Berberine

Author(s)

Keywords

Berberine

Cyclooxygenase

Histamine (H1) receptor

Nitric oxide

Relaxation

Smooth muscle

Trachea

Abstract

In this study we aimed to examine the relaxant effect of Berberine, a compound extracted from a variety of herbs, on rat Tracheal Smooth muscle (TSM) and its possible mechanism(s). Cumulative concentrations of Berberine (20, 65, 200 and 600 μ g/mL) were added on precontracted TSM by methacholine or KCl in non-incubated or incubated tissues with atropine, chlorpheniramine, propranolol, diltiazem, glibenclamide, indomethacin, L-NGnitro arginine methyl ester (L-NAME) and papaverine. The relaxant effects of theophylline (0. 2, 0. 4, 0. 6 and 0. 8 mM) as positive control and saline (1 mL) as negative control were also examined in non-incubated tissues. Berberine showed significant and concentration-dependent relaxant effects in nonincubated tissues contracted by KCl and methacholine (p<0. 01 to p<0. 001). There was no significant difference in the relaxant effects of Berberine between non-incubated and incubated tissues with atropine, propranolol, diltiazem, glibenclamide, and papaverine. The relaxant effects of second concentrations of Berberine in incubated tissues with L-NAME, its three lower concentration in incubated tissues with chlorpheniramine and its all concentrations in incubated tissues with indomethacin were significantly lower than nonincubated tissues (p<0. 05 to p<0. 001). The EC50 values of Berberine in incubated tissues with chlorpheniramine was significantly higher than the non-incubated condition (p<0. 05). Our findings reveal a relatively potent relaxant effect of Berberine that is lower than the effect of theophylline. Proposed mechanisms for the relaxant effect of Berberine are histamine (H1) receptor blockade, inhibition of Cyclooxygenase pathways and/or Nitric oxide formation.

Cites

Contribution of potassium channels, beta2-adrenergic and histamine H1 receptors in the relaxant effect of baicalein on rat tracheal smooth muscle

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APA: Copy

SAADAT, SAEIDEH, NAGHDI, FARZANEH, Ghorani, Vahideh, RAKHSHANDEH, HASSAN, & BOSKABADY, MOHAMMAD HOSSEIN. (2019). Histamine (H1) Receptors, Cyclooxygenase Pathway and Nitric Oxide Formation Involved in Rat Tracheal Smooth Muscle Relaxant Effect of Berberine. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(3), 320-331. SID. https://sid.ir/paper/291567/en

Vancouver: Copy

SAADAT SAEIDEH, NAGHDI FARZANEH, Ghorani Vahideh, RAKHSHANDEH HASSAN, BOSKABADY MOHAMMAD HOSSEIN. Histamine (H1) Receptors, Cyclooxygenase Pathway and Nitric Oxide Formation Involved in Rat Tracheal Smooth Muscle Relaxant Effect of Berberine. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(3):320-331. Available from: https://sid.ir/paper/291567/en

IEEE: Copy

SAEIDEH SAADAT, FARZANEH NAGHDI, Vahideh Ghorani, HASSAN RAKHSHANDEH, and MOHAMMAD HOSSEIN BOSKABADY, “Histamine (H1) Receptors, Cyclooxygenase Pathway and Nitric Oxide Formation Involved in Rat Tracheal Smooth Muscle Relaxant Effect of Berberine,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 3, pp. 320–331, 2019, [Online]. Available: https://sid.ir/paper/291567/en

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