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Information Journal Paper

Title

Interleukin-18 Polymorphisms Deficiency Association with Asthma Risk: An Update Meta-analysis

Pages

  351-361

Abstract

 Growing evidence indicated conflicting results that Interleukin-18 (IL-18) promoter polymorphisms rs1946518 (A-607C), rs187238 (G-137C) and rs549908 (A-105C) were associated with Asthma risk. The aim of this study is to comprehensively evaluate the IL-18 polymorphisms and Asthma by a systematic review and Meta-analysis. A total of 12 studies testing the association between these polymorphisms and Asthma were examined (8 studies for A-607C, 8 studies for G-137C, and 4 studies for A-105C) in the update metaanalysis, up to Dec 30, 2017. Summary odds ratios (ORs) and 95% confidence intervals (CI) were used to estimate the strength of association between each polymorphism and Asthma using fixed-and random-effects models when appropriate. Heterogeneity and publication bias were evaluated. The Meta-analysis results indicated that any allele frequencies of the IL-18 polymorphisms (A-607C, G-137C and A-105C) was not associated with Asthma risk (p>0. 05). And no statistically significant association was observed between genotype frequencies of these polymorphisms and Asthma under different genetic models (p>0. 05). Subgroup analysis results were similar to the main analysis by ethnicity, sample size, genotyping methods, matching criteria and quality score. There was no evidence of publication bias. The present Meta-analysis suggests that IL-18 polymorphisms (A-607C, G-137C and A-105C) were unlikely to be associated with Asthma risk.

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    • Cite

    APA: Copy

    LIU, HUAN, FENG, YUE, ZHANG, WEI, Deng, Xiao Dong, MA, YING, & LIU, YUN. (2019). Interleukin-18 Polymorphisms Deficiency Association with Asthma Risk: An Update Meta-analysis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(3), 351-361. SID. https://sid.ir/paper/291572/en

    Vancouver: Copy

    LIU HUAN, FENG YUE, ZHANG WEI, Deng Xiao Dong, MA YING, LIU YUN. Interleukin-18 Polymorphisms Deficiency Association with Asthma Risk: An Update Meta-analysis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(3):351-361. Available from: https://sid.ir/paper/291572/en

    IEEE: Copy

    HUAN LIU, YUE FENG, WEI ZHANG, Xiao Dong Deng, YING MA, and YUN LIU, “Interleukin-18 Polymorphisms Deficiency Association with Asthma Risk: An Update Meta-analysis,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 3, pp. 351–361, 2019, [Online]. Available: https://sid.ir/paper/291572/en

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