Studying the Serum as Well as Serous Level of IL-17 and IL-23 in Patients with Serous Otitis Media

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Yeghaneh Moghaddam Ahmad; Talaei Rezvan; NIKOUEINEJAD HASSAN; AKBARI HOSSEIN

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2017 | Volume:16 | Issue:6 Page(s): 520-524

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Title

Studying the Serum as Well as Serous Level of IL-17 and IL-23 in Patients with Serous Otitis Media

Author(s)

Yeghaneh Moghaddam Ahmad | Talaei Rezvan | NIKOUEINEJAD HASSAN | AKBARI HOSSEIN | Issue Writer Certificate

Keywords

Interleukin 17

Interleukin 23

Otitis media with effusion

Abstract

Serous Otitis media with effusion (OME) is a middle ear inflammatory response to allergens and microbes which stimulate leukocytes to produce different inflammatory mediators after obstruction of Eustachian tube. Here, we investigated the levels of these mediators, IL-17 and IL-23, in serum and middle ear fluids of children with OME. 75 patients with otitis media and 75 age and sex-matched healthy controls were enrolled in this study. IL-17 and IL-23 levels in serous secretion of the patients and their serum levels were measured in both groups by ELISA. Serum IL-17 levels were significantly higher in the patients than controls (p=0. 001). There was no significant difference between serum IL-23 levels in patients and controls. Patients’ serous levels of both cytokines of IL-17 and IL-23 were higher than those in serum according to different parameters of sex, age, and duration of the disease. This study shows an elevated presence of IL-17 and IL-23, as pro inflammatory cytokines, in OME. These finding may represent the contribution of such cytokines in the pathogenesis of OME. Blocking such molecules may yield new non-surgical therapeutics.

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APA: Copy

Yeghaneh Moghaddam, Ahmad, Talaei, Rezvan, NIKOUEINEJAD, HASSAN, & AKBARI, HOSSEIN. (2017). Studying the Serum as Well as Serous Level of IL-17 and IL-23 in Patients with Serous Otitis Media. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 16(6), 520-524. SID. https://sid.ir/paper/291589/en

Vancouver: Copy

Yeghaneh Moghaddam Ahmad, Talaei Rezvan, NIKOUEINEJAD HASSAN, AKBARI HOSSEIN. Studying the Serum as Well as Serous Level of IL-17 and IL-23 in Patients with Serous Otitis Media. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2017;16(6):520-524. Available from: https://sid.ir/paper/291589/en

IEEE: Copy

Ahmad Yeghaneh Moghaddam, Rezvan Talaei, HASSAN NIKOUEINEJAD, and HOSSEIN AKBARI, “Studying the Serum as Well as Serous Level of IL-17 and IL-23 in Patients with Serous Otitis Media,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 16, no. 6, pp. 520–524, 2017, [Online]. Available: https://sid.ir/paper/291589/en

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