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Information Journal Paper

Title

Altered Expression of miR-326 in T Cell-derived Exosomes of Patients with Relapsing-remitting Multiple Sclerosis

Pages

  108-113

Abstract

 Invasion of auto-reactive CD4+ T cells especially Th17 into central nervous system (CNS) is an underlying pathogenic mechanism in Multiple sclerosis (MS). CD4+ T cells release Exosomes which are enriched in microRNAs, reflective of cell’ s physiological or pathological condition. Thus Exosomes could be potent agents to provide quantitative and qualitative information about involved cells in MS. We investigated the expression of pathogenic microRNAs in T cells-derived Exosomes of MS patients or healthy controls. Conventional T cells (Tconv) derived from relapsing-remitting (RR) MS patients (n=10) and healthy controls (n=10) were purified and cultured for 3 days by soluble anti-CD3/CD28. Exosomes were purified from cultured-T cells supernatants. The expression levels of exosomal miR-146a, miR-29a, miR-155, and miR-326 were quantified by real-time PCR. A statistically significant increased expression of miR-326 in Tconv-derived Exosomes was observed in RRMS patients as compared with controls (7. 5± 1. 88vs 2. 51± 0. 9 p=0. 03), On the contrary, no differences were found in the expression levels of miR-155, miR-146a, and miR-29a, in Tconv-derived Exosomes of patients as compared with controls (p>0. 05). Our results point to altered expression in Exosome-derived microRNAs. MiR-326 was previously shown to play a role in the immunopathogenesis of MS by inducing TH17 differentiation and maturation. Therefore, miR-326 containing Exosomes might also be a potential clinical target in course of MS. Moreover, the deregulation of this miRNA in Exosomes may serve as a diagnostic and prognostic biomarker.

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    Cite

    APA: Copy

    AZIMI, MARYAM, GHABAEE, MOJDEH, NASER MOGHADASI, ABDORREZA, & IZAD, MARYAM. (2019). Altered Expression of miR-326 in T Cell-derived Exosomes of Patients with Relapsing-remitting Multiple Sclerosis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(1), 108-113. SID. https://sid.ir/paper/291592/en

    Vancouver: Copy

    AZIMI MARYAM, GHABAEE MOJDEH, NASER MOGHADASI ABDORREZA, IZAD MARYAM. Altered Expression of miR-326 in T Cell-derived Exosomes of Patients with Relapsing-remitting Multiple Sclerosis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(1):108-113. Available from: https://sid.ir/paper/291592/en

    IEEE: Copy

    MARYAM AZIMI, MOJDEH GHABAEE, ABDORREZA NASER MOGHADASI, and MARYAM IZAD, “Altered Expression of miR-326 in T Cell-derived Exosomes of Patients with Relapsing-remitting Multiple Sclerosis,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 1, pp. 108–113, 2019, [Online]. Available: https://sid.ir/paper/291592/en

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