Hematological Improvement of Patients with Active Rheumatoid Arthritis by β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property

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AHMADI HOSSEIN; JAMSHIDI AHMAD REZA; MAHMOUDI MAHDI; GHARIBDOOST FARHAD; VOJDANIAN MAHDI; FATTAHI MOHAMMAD JAVAD; RASTKARI NOUSHIN; Aghazadeh Zahra; MIRSHAFIEY ABBAS

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2017 | Volume:16 | Issue:5 Page(s): 433-442

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Title

Hematological Improvement of Patients with Active Rheumatoid Arthritis by β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property

Author(s)

Keywords

Anemia

Inflammation

Interleukin

Mannuronic acid

M2000

Rheumatoid arthritis

Therapy

Abstract

The aim of this study was to investigate the effect of β-D-Mannuronic acid (M2000) on hematological parameters in patients with active Rheumatoid arthritis. This study was conducted on 25 patients with active Rheumatoid arthritis (RA) (identifier: IRCT2014011213739N2). M2000 was administered orally for anemic and non-anemic RA patients at a dose of 500 mg twice daily for 12 weeks. The patients were permitted to continue the conventional treatments excluding NSAIDs. Blood samples were collected at baseline, 4 and 12 weeks after drug administration and were tested for hematological parameters. Moreover, serum levels of TNF-α and IL-6 were analysed before and after M2000 Therapy compared to healthy controls using enzyme linked immunosorbent assay method. We found a significant increase in the count of red blood cells and also hemoglobin (Hb) concentration (0. 9 g/dL) in anemic patients after 12 weeks of M2000 Therapy (p<0. 02 and p<0. 01, respectively). Furthermore, our results showed an improvement in Hb level (0. 45 g/dL) even in non-anemic patients who were treated by M2000 (p<0. 04). The leukocytosis in RA patients, significantly decreased in both anemic and non-anemic patients after 12 weeks of M2000 Therapy (p<0. 02 and p<0. 03, respectively). The percent of neutrophils significantly increased in anemic patients (p<0. 01) while in non-anemic patients it significantly decreased after 12 weeks of M2000 Therapy (p<0. 01). The serum levels of IL-6 and TNF-α significantly decreased after 12 weeks of M2000 Therapy (p<0. 01 and p<0. 04, respectively). M2000 improves hematological parameters in RA patients by its potent inhibitory effect on serum levels of TNF-α and IL-6.

Cites

Non-Requirement to Blood Transfusion in a Patient With Myelodysplastic Syndrome Following the Oral Administration of β-D-Mannuronic Acid: A Case Report

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APA: Copy

AHMADI, HOSSEIN, JAMSHIDI, AHMAD REZA, MAHMOUDI, MAHDI, GHARIBDOOST, FARHAD, VOJDANIAN, MAHDI, FATTAHI, MOHAMMAD JAVAD, RASTKARI, NOUSHIN, Aghazadeh, Zahra, & MIRSHAFIEY, ABBAS. (2017). Hematological Improvement of Patients with Active Rheumatoid Arthritis by β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 16(5), 433-442. SID. https://sid.ir/paper/291633/en

Vancouver: Copy

AHMADI HOSSEIN, JAMSHIDI AHMAD REZA, MAHMOUDI MAHDI, GHARIBDOOST FARHAD, VOJDANIAN MAHDI, FATTAHI MOHAMMAD JAVAD, RASTKARI NOUSHIN, Aghazadeh Zahra, MIRSHAFIEY ABBAS. Hematological Improvement of Patients with Active Rheumatoid Arthritis by β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2017;16(5):433-442. Available from: https://sid.ir/paper/291633/en

IEEE: Copy

HOSSEIN AHMADI, AHMAD REZA JAMSHIDI, MAHDI MAHMOUDI, FARHAD GHARIBDOOST, MAHDI VOJDANIAN, MOHAMMAD JAVAD FATTAHI, NOUSHIN RASTKARI, Zahra Aghazadeh, and ABBAS MIRSHAFIEY, “Hematological Improvement of Patients with Active Rheumatoid Arthritis by β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 16, no. 5, pp. 433–442, 2017, [Online]. Available: https://sid.ir/paper/291633/en

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