INTERLEUKIN-12 AND TUMOR NECROSIS FACTOR-B GENE POLYMORPHISMS AS GENETIC SUSCEPTIBILITY FACTORS FOR BRUCELLOSIS IN IRANIAN PATIENTS

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RASOULI M.; KIANI S.; MORAVEJ A.; KALANI M.

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Journal Paper

Paper Information

Journal: Iranian Red Crescent Medical Journal Year:2010 | Volume:12 | Issue:3 Page(s): 266-271

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Title

INTERLEUKIN-12 AND TUMOR NECROSIS FACTOR-B GENE POLYMORPHISMS AS GENETIC SUSCEPTIBILITY FACTORS FOR BRUCELLOSIS IN IRANIAN PATIENTS

Author(s)

RASOULI M. | KIANI S. | MORAVEJ A. | KALANI M. | Issue Writer Certificate

Keywords

BRUCELLA

GENETIC POLYMORPHISMS

INTERLEUKIN-12

TUMOR NECROSIS FACTOR-β

IRAN

Abstract

Background: Some reports suggest that the cytokine gene polymorphisms can contribute to the resistance or susceptibility to brucellosis. The aim of this study was to find out any probable association of GENETIC POLYMORPHISMS of INTERLEUKIN-12 (+1188 NC) and TNF-beta (+252 A/G) with susceptibility to the disease. Methods: One hundred and ninety-six patients with brucellosis and 81 healthy farmers (controls) who owned infected animals and consumed their contaminated dairy products were included in this study. IL-12 (+1188 NC) and TNF-beta (+252 A/G) genotyping were carried out for all of the subjects. Results: The results showed that the frequencies of IL-12 AA genotype and A allele were higher in controls than in patients while TNF-beta AA genotype and A allele were significantly higher in patients compared to the controls. Conclusion: These findings suggest that the inheritance of the above-mentioned genotypes and alleles can be considered as genetic factors conferring resistance or susceptibility to brucellosis.

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APA: Copy

RASOULI, M., KIANI, S., MORAVEJ, A., & KALANI, M.. (2010). INTERLEUKIN-12 AND TUMOR NECROSIS FACTOR-B GENE POLYMORPHISMS AS GENETIC SUSCEPTIBILITY FACTORS FOR BRUCELLOSIS IN IRANIAN PATIENTS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 12(3), 266-271. SID. https://sid.ir/paper/292205/en

Vancouver: Copy

RASOULI M., KIANI S., MORAVEJ A., KALANI M.. INTERLEUKIN-12 AND TUMOR NECROSIS FACTOR-B GENE POLYMORPHISMS AS GENETIC SUSCEPTIBILITY FACTORS FOR BRUCELLOSIS IN IRANIAN PATIENTS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2010;12(3):266-271. Available from: https://sid.ir/paper/292205/en

IEEE: Copy

M. RASOULI, S. KIANI, A. MORAVEJ, and M. KALANI, “INTERLEUKIN-12 AND TUMOR NECROSIS FACTOR-B GENE POLYMORPHISMS AS GENETIC SUSCEPTIBILITY FACTORS FOR BRUCELLOSIS IN IRANIAN PATIENTS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 12, no. 3, pp. 266–271, 2010, [Online]. Available: https://sid.ir/paper/292205/en

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