EFFECTS OF VITAMIN D AND CALCIUM SUPPLEMENTATION ON MICRO-ARCHITECTURAL AND DENSITOMETRIC CHANGES OF RAT FEMUR IN A MICROGRAVITY SIMULATOR MODEL

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KOUHNAVARD MARJAN; NASLI ESFAHANI ENSIEH; MONTAZERI MOHAMMAD; HASHEMIAN SEYED JAFAR; MEHRAZMA MITRA; LARIJANI BAGHER; NEZAMI ASL AMIR; KHOSHVAGHTI AMIR; FALSAFI AMMAR; LALEHFAR KOMEIL; MALEKPOUR KEYVAN; VOSUGH MEHRAN

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Journal: Iranian Red Crescent Medical Journal Year:2014 | Volume:16 | Issue:6 Page(s): 1-6

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Title

EFFECTS OF VITAMIN D AND CALCIUM SUPPLEMENTATION ON MICRO-ARCHITECTURAL AND DENSITOMETRIC CHANGES OF RAT FEMUR IN A MICROGRAVITY SIMULATOR MODEL

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Keywords

WEIGHTLESSNESS

BONE DENSITY

OSTEOPOROSIS

DIETARY SUPPLEMENTS

CALCIUM

VITAMIN D

Abstract

Background: Revealing data on the role of VITAMIN D and CALCIUM supplementation in bone health has led some to suggest that VITAMIN D and CALCIUM treatment could also play a role in protecting bone against microgravity-induced mineral loss.Objectives: The aim of the present study was to investigate the effects of VITAMIN D and CALCIUM administration on microscopic and densitometric changes of rat femur in a Microgravity Simulator Model.Materials and Methods: After designing a Microgravity Simulator Model, 14 rats were placed in the cages as follows: seven rats as OSTEOPOROSIS group and seven rats received oral supplement of CALCIUM/vitamin D as the treatment group. Animals were sacrificed after eight weeks and then both femurs were removed. Bone mineral density was measured for one femur from each animal, and morphologic studies were evaluated for the contralateral femur.Results: Bone mineral density of the whole femur in the treatment group was significantly higher than the OSTEOPOROSIS group (0.168±0.005 vs. 0.153±0.006, P=0.003). Also, bone mineral content of the whole femur was significantly higher in treatment group (0.415±0.016 vs. 0.372±0.019, P=0.003). However, resorption eroded surface percentage was higher in the OSTEOPOROSIS group (18.86±3.71% vs. 9.71±1.61%, P=0.002).Conclusions: According to the results of this study, VITAMIN D and CALCIUM administration might have protective effects against microgravity-induced mineral loss in a Rat Microgravity Simulator Model.

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APA: Copy

KOUHNAVARD, MARJAN, NASLI ESFAHANI, ENSIEH, MONTAZERI, MOHAMMAD, HASHEMIAN, SEYED JAFAR, MEHRAZMA, MITRA, LARIJANI, BAGHER, NEZAMI ASL, AMIR, KHOSHVAGHTI, AMIR, FALSAFI, AMMAR, LALEHFAR, KOMEIL, MALEKPOUR, KEYVAN, & VOSUGH, MEHRAN. (2014). EFFECTS OF VITAMIN D AND CALCIUM SUPPLEMENTATION ON MICRO-ARCHITECTURAL AND DENSITOMETRIC CHANGES OF RAT FEMUR IN A MICROGRAVITY SIMULATOR MODEL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 16(6), 1-6. SID. https://sid.ir/paper/292617/en

Vancouver: Copy

KOUHNAVARD MARJAN, NASLI ESFAHANI ENSIEH, MONTAZERI MOHAMMAD, HASHEMIAN SEYED JAFAR, MEHRAZMA MITRA, LARIJANI BAGHER, NEZAMI ASL AMIR, KHOSHVAGHTI AMIR, FALSAFI AMMAR, LALEHFAR KOMEIL, MALEKPOUR KEYVAN, VOSUGH MEHRAN. EFFECTS OF VITAMIN D AND CALCIUM SUPPLEMENTATION ON MICRO-ARCHITECTURAL AND DENSITOMETRIC CHANGES OF RAT FEMUR IN A MICROGRAVITY SIMULATOR MODEL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2014;16(6):1-6. Available from: https://sid.ir/paper/292617/en

IEEE: Copy

MARJAN KOUHNAVARD, ENSIEH NASLI ESFAHANI, MOHAMMAD MONTAZERI, SEYED JAFAR HASHEMIAN, MITRA MEHRAZMA, BAGHER LARIJANI, AMIR NEZAMI ASL, AMIR KHOSHVAGHTI, AMMAR FALSAFI, KOMEIL LALEHFAR, KEYVAN MALEKPOUR, and MEHRAN VOSUGH, “EFFECTS OF VITAMIN D AND CALCIUM SUPPLEMENTATION ON MICRO-ARCHITECTURAL AND DENSITOMETRIC CHANGES OF RAT FEMUR IN A MICROGRAVITY SIMULATOR MODEL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 16, no. 6, pp. 1–6, 2014, [Online]. Available: https://sid.ir/paper/292617/en

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