IMPROVEMENT OF CONTUSED SPINAL CORD IN RATS BY CHOLINERGIC-LIKE NEURON THERAPY

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NAGHDI MAJID; TIRAIHI TAKI; MESBAH NAMIN SEYED ALIREZA; ARABKHARADMAND JALIL; KAZEMI HADI; TAHERI TAHER

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Journal Paper

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Journal: Iranian Red Crescent Medical Journal Year:2013 | Volume:15 | Issue:2 Page(s): 127-135

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Title

IMPROVEMENT OF CONTUSED SPINAL CORD IN RATS BY CHOLINERGIC-LIKE NEURON THERAPY

Author(s)

Keywords

SPINAL CORD INJURIES

CONTUSIONS

CHOLINERGIC NEURONS

TISSUE THERAPY

Abstract

Background: Disability in spinal cord injury is an important medical problem, and cell transplantation is considered as an option for the treatment.Objectives: The purpose of this study is to use bone marrow stromal cells (BMSCs) derived cholinergic neuron-like cells (CNL) in order to ameliorate the contusion model of spinal cord injury in rats.Materials and Methods: The CNLs were produced by pre inducing BMSCs with b-mercaptoethanol (BME) followed by inducing with nerve growth factor (NGF). The cells were immunoreactive to neurofilament 200, NeuN, synaptophysin, synapsin, microtubule associated protein-2 and choline acetyl transferase (ChAT). The CNL were transplanted in contused rats (CR), which were sacrificed after 12 weeks.Results: The results showed that BBB test showed an improvement in the CR, while the quantitative analysis showed that the improvement rate was higher in the rats treated with CNL than those treated with BMSCs only or the untreated animals, similar results were noticed in the improvement index. Immunohistochemical analysis of the tissue section prepared from the CR showed that the transplanted cells were engrafted and integrated in the traumatized spinal cord. The morphometric analysis showed that the volume density of the cavity in the CNL treated rats was significantly lower than that of the untreated ones, while the spinal tissue regeneration index was significantly higher.Conclusions: The conclusion of the study is that CNL can improve the injured spinal cord.

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APA: Copy

NAGHDI, MAJID, TIRAIHI, TAKI, MESBAH NAMIN, SEYED ALIREZA, ARABKHARADMAND, JALIL, KAZEMI, HADI, & TAHERI, TAHER. (2013). IMPROVEMENT OF CONTUSED SPINAL CORD IN RATS BY CHOLINERGIC-LIKE NEURON THERAPY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 15(2), 127-135. SID. https://sid.ir/paper/292816/en

Vancouver: Copy

NAGHDI MAJID, TIRAIHI TAKI, MESBAH NAMIN SEYED ALIREZA, ARABKHARADMAND JALIL, KAZEMI HADI, TAHERI TAHER. IMPROVEMENT OF CONTUSED SPINAL CORD IN RATS BY CHOLINERGIC-LIKE NEURON THERAPY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2013;15(2):127-135. Available from: https://sid.ir/paper/292816/en

IEEE: Copy

MAJID NAGHDI, TAKI TIRAIHI, SEYED ALIREZA MESBAH NAMIN, JALIL ARABKHARADMAND, HADI KAZEMI, and TAHER TAHERI, “IMPROVEMENT OF CONTUSED SPINAL CORD IN RATS BY CHOLINERGIC-LIKE NEURON THERAPY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 15, no. 2, pp. 127–135, 2013, [Online]. Available: https://sid.ir/paper/292816/en

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