THE ROLE OF VITAMIN C IN PREVENTION OF PRETERM PREMATURE RUPTURE OF MEMBRANES

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GHOMIAN NAYEREH; HAFIZI LEILI; TAKHTI ZAHRA

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Journal Paper

Paper Information

Journal: Iranian Red Crescent Medical Journal Year:2013 | Volume:15 | Issue:2 Page(s): 113-116

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Title

THE ROLE OF VITAMIN C IN PREVENTION OF PRETERM PREMATURE RUPTURE OF MEMBRANES

Author(s)

GHOMIAN NAYEREH | HAFIZI LEILI | TAKHTI ZAHRA | Issue Writer Certificate

Keywords

ASCORBIC ACID

PREGNANCY

FETAL MEMBRANES

PREMATURE RUPTURE

PREVENTION AND CONTROL

Abstract

Background: Preterm PREMATURE RUPTURE of membranes (PPROM) is one of the most important complications of the PREGNANCY and cause perinatal morbidity and mortality. History of PPROM is a risk factor of recurrent PPROM. Vitamin C plays an important role in collagen metabolism and increases resistance maintenance of the chorioamniotic membranes.Objectives: The aim of this study is to evaluate the role of vitamin C supplementation in prevention of PPROM in women with a positive history of PPROM.Patients and Methods: This clinical trial study was performed on 170 pregnant women with the history of PPROM, with singleton PREGNANCY and gestational age 14 weeks in Imam-Reza Hospital, Mashhad University of Medical Sciences during 2008 to 2010. They were randomly divided into two groups. The case patients received 100 mg vitamin C daily from 14th weeks of gestation. PPROM occurrence was compared between two groups as an indicator of the protective effect of vitamin C supplements.Results: PPROM occurred in 44.7% of controls and 31.8% of cases (P dlt; 0.05). PROM occurred in 34.1% of controls and 18.8% of cases (P dlt; 0.05). PREGNANCY was terminated at term gestation in 21.2% of controls and 49.4% of cases (P dlt; 0.05). Rupture of membranes was significantly decreased in the case group. Conclusions: Vitamin C supplementations after 14th weeks of gestation can prevent from PPROM in women with the history of PPROM.

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APA: Copy

GHOMIAN, NAYEREH, HAFIZI, LEILI, & TAKHTI, ZAHRA. (2013). THE ROLE OF VITAMIN C IN PREVENTION OF PRETERM PREMATURE RUPTURE OF MEMBRANES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 15(2), 113-116. SID. https://sid.ir/paper/292822/en

Vancouver: Copy

GHOMIAN NAYEREH, HAFIZI LEILI, TAKHTI ZAHRA. THE ROLE OF VITAMIN C IN PREVENTION OF PRETERM PREMATURE RUPTURE OF MEMBRANES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2013;15(2):113-116. Available from: https://sid.ir/paper/292822/en

IEEE: Copy

NAYEREH GHOMIAN, LEILI HAFIZI, and ZAHRA TAKHTI, “THE ROLE OF VITAMIN C IN PREVENTION OF PRETERM PREMATURE RUPTURE OF MEMBRANES,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 15, no. 2, pp. 113–116, 2013, [Online]. Available: https://sid.ir/paper/292822/en

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