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Information Journal Paper

Title

GENETIC ANALYSIS OF CAGA AND VACA GENES IN HELICOBACTER PYLORI ISOLATES AND THEIR RELATIONSHIP WITH GASTRODUODENAL DISEASES IN THE WEST OF IRAN

Pages

  371-375

Abstract

 Background: HELICOBACTER PYLORI have different virulence factors which are associated with several gastroduodenal diseases; however, this association is variable in different geographical regions. Data of genotypes of Iranian H. pylori isolates are few.Objectives: The aim of the current study was to investigate the cagA/vacA genotypes of HELICOBACTER PYLORI isolates and determine the relationship between these genotypes with respect to different gastric disorders in patients of Chaharmahalo Bakhtiarian.Materials and Methods: In this cross-sectional study, gastric biopsies were taken from 200 patients with gastrodoudenal diseases. Histopathological features were recognized by specialist. The samples were subjected to PCR for detection and identification of ureC, cagA and vacA genes.Results: The frequency of the vacA genotypes, sa1/m1, s1a/m1b, s1a/m2, s1b/m1a, s1b/m1b, s1b/m2, s1c/m1a, s1c/m1b, s1c/m2, s2/m1a, s2/m1b and s2/ m2 were 27 (6.6%), 8 (4.3%), 45 (28.04%), 7 (3.7%), 5 (2.5%), 10 (6.1%), 12 (7.4%), 4 (2.5%), 18 (11%), 6 (3.7%), 0 and 22 (13.5%) respectively. The cagA gene was detected in 92% of strains. Based on our findings, it seemed that cagPAI and vacA s1 genotypes were associated with some gastric disorders in patients with H. pylori. In this region, the isolates carrying s1a/m2 were the most prevalent.Conclusions: We found considerable relationship between s1a/m1a, s1a/m2, s2/m2 and s1c/m1a and some gastric disorders. Further studies about the role of H. pylori virulence factors and gastric disorders were recommended.

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    • Cite

    APA: Copy

    SOUOD, NEGAR, KARGAR, MOHAMMAD, DOOSTI, ABBAS, RANJBAR, REZA, & SARSHAR, MEYSAM. (2013). GENETIC ANALYSIS OF CAGA AND VACA GENES IN HELICOBACTER PYLORI ISOLATES AND THEIR RELATIONSHIP WITH GASTRODUODENAL DISEASES IN THE WEST OF IRAN. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 15(5), 371-375. SID. https://sid.ir/paper/292878/en

    Vancouver: Copy

    SOUOD NEGAR, KARGAR MOHAMMAD, DOOSTI ABBAS, RANJBAR REZA, SARSHAR MEYSAM. GENETIC ANALYSIS OF CAGA AND VACA GENES IN HELICOBACTER PYLORI ISOLATES AND THEIR RELATIONSHIP WITH GASTRODUODENAL DISEASES IN THE WEST OF IRAN. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2013;15(5):371-375. Available from: https://sid.ir/paper/292878/en

    IEEE: Copy

    NEGAR SOUOD, MOHAMMAD KARGAR, ABBAS DOOSTI, REZA RANJBAR, and MEYSAM SARSHAR, “GENETIC ANALYSIS OF CAGA AND VACA GENES IN HELICOBACTER PYLORI ISOLATES AND THEIR RELATIONSHIP WITH GASTRODUODENAL DISEASES IN THE WEST OF IRAN,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 15, no. 5, pp. 371–375, 2013, [Online]. Available: https://sid.ir/paper/292878/en

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