COMPARING THE EFFECT OF PREOPERATIVE ADMINISTRATION OF METHYLPREDNISOLONE AND ITS ADMINISTRATION BEFORE AND DURING SURGERY ON THE CLINICAL OUTCOME IN PEDIATRIC OPEN HEART SURGERIES

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SOLTANI GHASEM; ABBASI TASHNIZI MOHAMMAD; MOEINIPOUR ALI ASGHAR; GANJIFARD MAHMOUD; ESFAHANIZADEH JAMIL; SEPEHRI SHAMLOO ALIREZA; PURAFZALI FIRUZABADI SEYED JAVAD; ZIRAK NAHID

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Journal: Iranian Red Crescent Medical Journal Year:2013 | Volume:15 | Issue:6 Page(s): 483-487

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Title

COMPARING THE EFFECT OF PREOPERATIVE ADMINISTRATION OF METHYLPREDNISOLONE AND ITS ADMINISTRATION BEFORE AND DURING SURGERY ON THE CLINICAL OUTCOME IN PEDIATRIC OPEN HEART SURGERIES

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Keywords

CARDIOPULMONARY BYPASS

HEART DEFECTS

INFLAMMATION

CONGENITAL

Abstract

Background: Cardiac surgery under CARDIOPULMONARY BYPASS causes a systemic inflammatory response with a multifactorial etiology including direct tissue damage, ischemia and stimulation of immune system induced by CARDIOPULMONARY BYPASS. This study was designed due to the high prevalence and complications of this stimulated immune system in mortality, morbidity, length of ICU stay, and mechanical ventilation.Objectives: This study was aimed to compare preoperative and intraoperative methylprednisolone (MP) to intraoperative MP alone with respect to postbypass INFLAMMATION and clinical outcome.Patients and Methods: Sixty pediatric patients (age<5years) undergoing CARDIOPULMONARY BYPASS surgery between September 2011-2012 at Imam Reza hospital-Mashhad were randomly assigned to receive preoperative and intraoperative MP (group 1: 30 mg/kg, 4 hours before bypass and in bypass prime, n=30) or intraoperative MP only (group 2: 30 mg/kg, n=30). Postoperative temperature (peak temperature and average temperature during the first 24 hours), amount of inotropic, duration of mechanical ventilation, ICU stay, WBC, BUN, creatinine, and CRP were recorded and compared in both groups. Data were analyzed with SPSS version 13 by T-test, Mann-Whitney test if necessary, and Chi-squared distribution.Results: Patient characteristics including age, weight, gender, and duration of bypass were almost similar in both groups (P>0.05). No significant difference in amount of inotropic medications used for hemodynamic supports, duration of mechanical ventilation, peak and average temperature and length of ICU stay was observed. Among the laboratory tests (WBC, BUN, creatinine, CRP) only WBC counts raised more in group 2 when compared to group 1 (P<0.05).Conclusions: There was no difference in clinical outcome after cardiac surgery when we administered an additional dose of methylprednisolone compared to a single dose of methylprednisolone.

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EFFICACY AND SAFETY OF ALUMINUM CHLORIDE IN CONTROLLING EXTERNAL HEMORRHAGE: AN ANIMAL MODEL STUDY

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APA: Copy

SOLTANI, GHASEM, ABBASI TASHNIZI, MOHAMMAD, MOEINIPOUR, ALI ASGHAR, GANJIFARD, MAHMOUD, ESFAHANIZADEH, JAMIL, SEPEHRI SHAMLOO, ALIREZA, PURAFZALI FIRUZABADI, SEYED JAVAD, & ZIRAK, NAHID. (2013). COMPARING THE EFFECT OF PREOPERATIVE ADMINISTRATION OF METHYLPREDNISOLONE AND ITS ADMINISTRATION BEFORE AND DURING SURGERY ON THE CLINICAL OUTCOME IN PEDIATRIC OPEN HEART SURGERIES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 15(6), 483-487. SID. https://sid.ir/paper/292887/en

Vancouver: Copy

SOLTANI GHASEM, ABBASI TASHNIZI MOHAMMAD, MOEINIPOUR ALI ASGHAR, GANJIFARD MAHMOUD, ESFAHANIZADEH JAMIL, SEPEHRI SHAMLOO ALIREZA, PURAFZALI FIRUZABADI SEYED JAVAD, ZIRAK NAHID. COMPARING THE EFFECT OF PREOPERATIVE ADMINISTRATION OF METHYLPREDNISOLONE AND ITS ADMINISTRATION BEFORE AND DURING SURGERY ON THE CLINICAL OUTCOME IN PEDIATRIC OPEN HEART SURGERIES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2013;15(6):483-487. Available from: https://sid.ir/paper/292887/en

IEEE: Copy

GHASEM SOLTANI, MOHAMMAD ABBASI TASHNIZI, ALI ASGHAR MOEINIPOUR, MAHMOUD GANJIFARD, JAMIL ESFAHANIZADEH, ALIREZA SEPEHRI SHAMLOO, SEYED JAVAD PURAFZALI FIRUZABADI, and NAHID ZIRAK, “COMPARING THE EFFECT OF PREOPERATIVE ADMINISTRATION OF METHYLPREDNISOLONE AND ITS ADMINISTRATION BEFORE AND DURING SURGERY ON THE CLINICAL OUTCOME IN PEDIATRIC OPEN HEART SURGERIES,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 15, no. 6, pp. 483–487, 2013, [Online]. Available: https://sid.ir/paper/292887/en

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