EFFECTS OF SIMVASTATIN TREATMENT ON SERUM ADIPONECTIN CONCENTRATIONS IN PATIENTS WITH DISLIPIDEMIA

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MOEZZI ATEFEH; PARIZADEH SEYYED MOHAMMAD REZA; TAVALLAIEE SHIMA; MAZIDI MOHSEN; AFZALI FARIBA; ADAB AFROUZ; FERNS GORDON; GHAYOUR MOBARHAN MAJID

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Journal: Iranian Red Crescent Medical Journal Year:2014 | Volume:16 | Issue:8 Page(s): 0-0

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Title

EFFECTS OF SIMVASTATIN TREATMENT ON SERUM ADIPONECTIN CONCENTRATIONS IN PATIENTS WITH DISLIPIDEMIA

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Keywords

ATHEROSCLEROSIS

ADIPONECTIN

STATINS

Abstract

Background: ADIPONECTIN is an adipose tissue-derived protein with anti-inflammatory properties. STATINS are a class of cholesterol-lowering drugs, widely used for treatment of cardiovascular diseases.Objectives: In the current study, we aimed to assess the effects of simvastatin on serum levels of ADIPONECTIN in patients with dyslipidemia, recruited from Ghaem Hospital, Mashhad, Iran.Materials and Methods: A total of 102 patients with dyslipidemia were treated with simvastatin or placebo during a double-blind, cross-over, placebo-controlled trial. The ADIPONECTIN levels were measured before and after each treatment period. Seventy seven participants completed the study.Results: There was a significant reduction in serum total cholesterol (approxmately 21%), low density lipoprotein-cholesterol (LDL-C) (approxmately 28%), and triglycerides (approxmately 11%), after four weeks of treatment with simvastatin (P<0.001).Conclusions: No significant change in serum ADIPONECTIN concentrations was observed after treatment with simvastatin. This may be because of the relatively short duration of treatment and longer treatment duration may be necessary to investigation in future studies.

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APA: Copy

MOEZZI, ATEFEH, PARIZADEH, SEYYED MOHAMMAD REZA, TAVALLAIEE, SHIMA, MAZIDI, MOHSEN, AFZALI, FARIBA, ADAB, AFROUZ, FERNS, GORDON, & GHAYOUR MOBARHAN, MAJID. (2014). EFFECTS OF SIMVASTATIN TREATMENT ON SERUM ADIPONECTIN CONCENTRATIONS IN PATIENTS WITH DISLIPIDEMIA. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 16(8), 0-0. SID. https://sid.ir/paper/292912/en

Vancouver: Copy

MOEZZI ATEFEH, PARIZADEH SEYYED MOHAMMAD REZA, TAVALLAIEE SHIMA, MAZIDI MOHSEN, AFZALI FARIBA, ADAB AFROUZ, FERNS GORDON, GHAYOUR MOBARHAN MAJID. EFFECTS OF SIMVASTATIN TREATMENT ON SERUM ADIPONECTIN CONCENTRATIONS IN PATIENTS WITH DISLIPIDEMIA. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2014;16(8):0-0. Available from: https://sid.ir/paper/292912/en

IEEE: Copy

ATEFEH MOEZZI, SEYYED MOHAMMAD REZA PARIZADEH, SHIMA TAVALLAIEE, MOHSEN MAZIDI, FARIBA AFZALI, AFROUZ ADAB, GORDON FERNS, and MAJID GHAYOUR MOBARHAN, “EFFECTS OF SIMVASTATIN TREATMENT ON SERUM ADIPONECTIN CONCENTRATIONS IN PATIENTS WITH DISLIPIDEMIA,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 16, no. 8, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/292912/en

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