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Title

A COMPARISON OF DEXMEDETOMIDINE, MOXONIDINE AND ALPHA-METHYLDOPA EFFECTS ON ACUTE, LETHAL COCAINE TOXICITY

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Abstract

 Background: The treatment of COCAINE toxicity is an important subject for emergency physicians. We investigated the effects of DEXMEDETOMIDINE, MOXONIDINE and ALPHA-METHYLDOPA on acute COCAINE toxicity in mice.Objectives: The aim of this study was to evaluate the effects of DEXMEDETOMIDINE, MOXONIDINE and ALPHA-METHYLDOPA in a mouse model of acute COCAINE toxicity.Materials and Methods: We performed an experiment consisting of four groups (n=25 each). The first group received normal saline solution, the second group received 40 mg/kg of DEXMEDETOMIDINE, the third group received 0.1 mg/kg of MOXONIDINE and the fourth group received 200 mg/kg of ALPHA-METHYLDOPA, all of which were intraperitoneally administered 10 minutes before COCAINE hydrochloride (105 mg/kg). All animals were observed for seizures (popcorn jumping, tonic-clonic activity, or a loss of the righting reflex) and lethality over the 30 minutes following COCAINE treatment.Results: The ratio of animals with convulsions was lower in all treated groups when compared to the control (P<0.001). Furthermore, 68% (n=17) of animals in the DEXMEDETOMIDINE group, 84% (n=21) of the ALPHA-METHYLDOPA group, 92% (n=23) of the MOXONIDINE group and 100% (n=25) of the control group showed evidence of seizure activity (P=0.009). COCAINE-induced lethality was observed in 12% (n=3) of the DEXMEDETOMIDINE group, 48% (n=12) of the ALPHA-METHYLDOPA group, 52% (n=13) of the MOXONIDINE group, and 72% (n=18) of the control group (P<0.001). All treatments prolonged the time to seizure, which was longest in the DEXMEDETOMIDINE group (P>0.05). In addition, the time to lethality was also longer in the same group (P<0.001).Conclusions: The present study provides the first experimental evidence in support of DEXMEDETOMIDINE treatment for COCAINE-induced seizures. Premedication with DEXMEDETOMIDINE reduces seizure activity in a mouse model of acute COCAINE toxicity. In addition, while DEXMEDETOMIDINE may be effective, MOXONIDINE and ALPHA-METHYLDOPA did not effectively prevent COCAINE-induced lethality.

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    APA: Copy

    SEYIT, MURAT, ERDUR, BULENT, KORTUNAY, SELIM, YUKSEL, AYKUT, YILMAZ, ATAKAN, OZEN, MERT, UYANIK, AYKUT, TOMRUK, ONDER, & ERGIN, AHMET. (2015). A COMPARISON OF DEXMEDETOMIDINE, MOXONIDINE AND ALPHA-METHYLDOPA EFFECTS ON ACUTE, LETHAL COCAINE TOXICITY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 17(6), 0-0. SID. https://sid.ir/paper/292964/en

    Vancouver: Copy

    SEYIT MURAT, ERDUR BULENT, KORTUNAY SELIM, YUKSEL AYKUT, YILMAZ ATAKAN, OZEN MERT, UYANIK AYKUT, TOMRUK ONDER, ERGIN AHMET. A COMPARISON OF DEXMEDETOMIDINE, MOXONIDINE AND ALPHA-METHYLDOPA EFFECTS ON ACUTE, LETHAL COCAINE TOXICITY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2015;17(6):0-0. Available from: https://sid.ir/paper/292964/en

    IEEE: Copy

    MURAT SEYIT, BULENT ERDUR, SELIM KORTUNAY, AYKUT YUKSEL, ATAKAN YILMAZ, MERT OZEN, AYKUT UYANIK, ONDER TOMRUK, and AHMET ERGIN, “A COMPARISON OF DEXMEDETOMIDINE, MOXONIDINE AND ALPHA-METHYLDOPA EFFECTS ON ACUTE, LETHAL COCAINE TOXICITY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 17, no. 6, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/292964/en

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