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Information Journal Paper

Title

INTERLEUKIN-2 EXPRESSION IN LUPOID AND USUAL TYPES OF OLD WORLD CUTANEOUS LEISHMANIASIS

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Abstract

 Background: Interleukin (IL) -2 plays a central role in T cell-dependent immune responses.Objectives: We conducted this study to determine and compare IL-2 expression in lupoid and usual types of Old World Cutaneous LEISHMANIASIS (OWCL), using immunohistochemistry.Patients and Methods: Thirteen paraffin-embedded specimens of lupoid and 12 specimens of usual types of OWCL were used. A mouse monoclonal anti IL-2 antibody was used for staining by the envision technique.Results: There were strongly stained discrete foci of staining through inflammatory infiltrates of dermis and also in basal layers of epidermis and adnexal structures, with a distinctive pattern of hot spot activity foci (mean of 9.31±6.4 versus 8.17±6.9 foci per HPF for lupoid and usual types, respectively). The expression of IL-2 had no correlation with the pattern of GRANULOMATOUS inflammation (tuberculoid, sarcoidal or mixed suppurative).Conclusions: INTERLEUKIN-2 takes part in the immunological response of the GRANULOMATOUS reaction of OWCL and is not statistically different between lupoid and usual types (P=0.674).

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    APA: Copy

    MASHAYEKHI GOYONLO, VAHID, ELNOUR, HESAMELDIN, & NORDLIND, KLAS. (2014). INTERLEUKIN-2 EXPRESSION IN LUPOID AND USUAL TYPES OF OLD WORLD CUTANEOUS LEISHMANIASIS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 16(11), 0-0. SID. https://sid.ir/paper/293007/en

    Vancouver: Copy

    MASHAYEKHI GOYONLO VAHID, ELNOUR HESAMELDIN, NORDLIND KLAS. INTERLEUKIN-2 EXPRESSION IN LUPOID AND USUAL TYPES OF OLD WORLD CUTANEOUS LEISHMANIASIS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2014;16(11):0-0. Available from: https://sid.ir/paper/293007/en

    IEEE: Copy

    VAHID MASHAYEKHI GOYONLO, HESAMELDIN ELNOUR, and KLAS NORDLIND, “INTERLEUKIN-2 EXPRESSION IN LUPOID AND USUAL TYPES OF OLD WORLD CUTANEOUS LEISHMANIASIS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 16, no. 11, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/293007/en

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