COMBINATION OF ANGIOTENSIN CONVERTING ENZYME INSERTION/DELETION (I/D) (RS4646994) AND VEGF POLYMORPHISM (+405G/C, RS2010963) SYNERGISTICALLY ASSOCIATED WITH THE DEVELOPMENT, OF ALBUMINURIA IN IRANIAN PATIENTS WITH TYPE 2 DIABETES

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FATHI MOHAMMAD; NIKZAMIR ABDOL RAHIM; ESTEGHAMATI ALIREZA; NAKHJAVANI MANOUCHEHR; YEKANINEJAD MIR SAEED

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Journal: Iranian Red Crescent Medical Journal Year:2015 | Volume:17 | Issue:2 Page(s): 0-0

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Title

COMBINATION OF ANGIOTENSIN CONVERTING ENZYME INSERTION/DELETION (I/D) (RS4646994) AND VEGF POLYMORPHISM (+405G/C, RS2010963) SYNERGISTICALLY ASSOCIATED WITH THE DEVELOPMENT, OF ALBUMINURIA IN IRANIAN PATIENTS WITH TYPE 2 DIABETES

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Keywords

VASCULAR ENDOTHELIAL GROWTH FACTOR

ALBUMINURIA

DIABETES MELLITUS

GENETIC POLYMORPHISM

Abstract

Background: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) polymorphisms have been shown to associate with diabetic nephropathy (DN).Objectives: We examined the hypothesis that ACE-D and VEGF-G alleles act synergistically in association with DN, in patients with type 2 DIABETES MELLITUS (T2DM).Patients and Methods: The VEGF (rs2010963) and ACE (rs4646994) genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 490 T2DM patients. Diabetic patients were classified as T2DM patients with and without ALBUMINURIA (control). The PCR and RFLP were used to detect the VEGF and ACE alleles.Results: A total of 255 consecutive patients with T2DM and microalbuminuria (Group A) and 235 patients with T2DM and normoalbuminuria (Group B) were included in the study. In univariate analysis, the groups were statistically similar for all variables, except for glycated hemoglobin (HbA1c) (P=0.034), and the frequency of ACE (P=0.015) and VEGF (P=0.006) genotypes. Our study showed that the VEGF-G and ACE-D alleles are independently associated with the development of nephropathy. According to our data, the combination of these two risk factors had a significant synergistic effect on the risk of microalbuminuria development.Conclusions: Our study indicated that ACE-D and VEGF-G alleles can be an independent risk factor for microalbominuria in T2DM patients.

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APA: Copy

FATHI, MOHAMMAD, NIKZAMIR, ABDOL RAHIM, ESTEGHAMATI, ALIREZA, NAKHJAVANI, MANOUCHEHR, & YEKANINEJAD, MIR SAEED. (2015). COMBINATION OF ANGIOTENSIN CONVERTING ENZYME INSERTION/DELETION (I/D) (RS4646994) AND VEGF POLYMORPHISM (+405G/C, RS2010963) SYNERGISTICALLY ASSOCIATED WITH THE DEVELOPMENT, OF ALBUMINURIA IN IRANIAN PATIENTS WITH TYPE 2 DIABETES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 17(2), 0-0. SID. https://sid.ir/paper/293066/en

Vancouver: Copy

FATHI MOHAMMAD, NIKZAMIR ABDOL RAHIM, ESTEGHAMATI ALIREZA, NAKHJAVANI MANOUCHEHR, YEKANINEJAD MIR SAEED. COMBINATION OF ANGIOTENSIN CONVERTING ENZYME INSERTION/DELETION (I/D) (RS4646994) AND VEGF POLYMORPHISM (+405G/C, RS2010963) SYNERGISTICALLY ASSOCIATED WITH THE DEVELOPMENT, OF ALBUMINURIA IN IRANIAN PATIENTS WITH TYPE 2 DIABETES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2015;17(2):0-0. Available from: https://sid.ir/paper/293066/en

IEEE: Copy

MOHAMMAD FATHI, ABDOL RAHIM NIKZAMIR, ALIREZA ESTEGHAMATI, MANOUCHEHR NAKHJAVANI, and MIR SAEED YEKANINEJAD, “COMBINATION OF ANGIOTENSIN CONVERTING ENZYME INSERTION/DELETION (I/D) (RS4646994) AND VEGF POLYMORPHISM (+405G/C, RS2010963) SYNERGISTICALLY ASSOCIATED WITH THE DEVELOPMENT, OF ALBUMINURIA IN IRANIAN PATIENTS WITH TYPE 2 DIABETES,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 17, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/293066/en

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