HAPLOTYPE ANALYSIS OF HEMOCHROMATOSIS GENE POLYMORPHISMS IN CHRONIC HEPATITIS C VIRUS INFECTION: A CASE CONTROL STUDY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GERAYLI SINA; PASDAR ALIREZA; SHAKERI MOHAMMAD TAGHI; SEPAHI SAMANEH; HOSEINI SEYED MOUSALREZA; AHADI MITRA; ROSTAMI SINA; MESHKAT ZAHRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:6 Page(s): 0-0

Download Full-Text

View:

279

Download:

198

Cites:

Information Journal Paper

Title

HAPLOTYPE ANALYSIS OF HEMOCHROMATOSIS GENE POLYMORPHISMS IN CHRONIC HEPATITIS C VIRUS INFECTION: A CASE CONTROL STUDY

Author(s)

Keywords

HEPATITIS C VIRUS

HEMOCHROMATOSIS (HFE) GENE POLYMORPHISMS

PROGNOSIS

Abstract

Background: Chronic HEPATITIS C VIRUS (HCV) infection is frequently associated with elevated serum iron markers. Polymorphisms in the hemochromatosis (HFE) genes are responsible for iron accumulation in most cases of hemochromatosis, and may play a role in HCV infection.Objectives: We aimed to assess the prevalence of HFE gene polymorphisms in a group of Iranian HCV-infected patients, and to explore the association of these polymorphisms with HCV infection.Patients and Methods: HFE gene polymorphisms were examined in a total of 69 HCV patients and 69 healthy controls using polymerase chain reaction and restriction fragment length polymorphism techniques. Haplotype and diplotype analyses were performed using PHASE software.Results: In a recessive analysis model of the His63Asp (H63D) locus (HHvs. HD+DD), the HH genotype was more common in patients compared to controls (adjusted P=0.012; OR=6.42 [95% CI: 1.51 - 27.33]). Also, in a recessive analysis model of the Cys282Tyr (C282Y) locus (CC vs. CY+YY), the CC genotype was more frequent in patients compared to controls (adjusted P=0.03; OR=5.06 [95% CI: 1.13 - 22.06]). In addition, there was a significant association between the HC haplotype and the HCDC diplotype and HCV infection.Conclusions: Polymorphism in the hemochromatosis gene may confer some degree of risk for HCV infection, and individuals carrying the H and C alleles may be susceptible to this disease; however, a larger sample of HCV patients and healthy individuals may be necessary to further illustrate the role of these polymorphisms in HCV.

Cites

No record.

References

HFE GENE MUTATIONS IN CRYPTOGENIC CIRRHOSIS PATIENTS

Cite

APA: Copy

GERAYLI, SINA, PASDAR, ALIREZA, SHAKERI, MOHAMMAD TAGHI, SEPAHI, SAMANEH, HOSEINI, SEYED MOUSALREZA, AHADI, MITRA, ROSTAMI, SINA, & MESHKAT, ZAHRA. (2016). HAPLOTYPE ANALYSIS OF HEMOCHROMATOSIS GENE POLYMORPHISMS IN CHRONIC HEPATITIS C VIRUS INFECTION: A CASE CONTROL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(6), 0-0. SID. https://sid.ir/paper/293271/en

Vancouver: Copy

GERAYLI SINA, PASDAR ALIREZA, SHAKERI MOHAMMAD TAGHI, SEPAHI SAMANEH, HOSEINI SEYED MOUSALREZA, AHADI MITRA, ROSTAMI SINA, MESHKAT ZAHRA. HAPLOTYPE ANALYSIS OF HEMOCHROMATOSIS GENE POLYMORPHISMS IN CHRONIC HEPATITIS C VIRUS INFECTION: A CASE CONTROL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(6):0-0. Available from: https://sid.ir/paper/293271/en

IEEE: Copy

SINA GERAYLI, ALIREZA PASDAR, MOHAMMAD TAGHI SHAKERI, SAMANEH SEPAHI, SEYED MOUSALREZA HOSEINI, MITRA AHADI, SINA ROSTAMI, and ZAHRA MESHKAT, “HAPLOTYPE ANALYSIS OF HEMOCHROMATOSIS GENE POLYMORPHISMS IN CHRONIC HEPATITIS C VIRUS INFECTION: A CASE CONTROL STUDY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 6, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293271/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops