مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

ASSESSING THE EPIDEMIOLOGY OF NEPHROTOXICITY AND THE ROLE OF URINARY KIDNEY INJURY MOLECULE 1 AS A BIOMARKER OF RENAL FUNCTION IN HEMATOLOGIC-ONCOLOGIC PATIENTS UNDER VANCOMYCIN TREATMENT IN SHIRAZ, IRAN

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Abstract

 Background: NEPHROTOXICITY is a common adverse effect of VANCOMYCIN. However, some aspects of VANCOMYCIN NEPHROTOXICITY have not been studied well in the Iranian population. Serum creatinine as a classic marker of renal function has several limitations in clinical practice.Objectives: To determine the incidence, time onset, and possible associated factors of VANCOMYCIN NEPHROTOXICITY, and compare the patterns and the accuracy of URINE KIDNEY INJURY MOLECULE 1 (KIM-1) with that of serum and URINE creatinine during VANCOMYCIN treatment.Methods: A longitudinal study was performed during 9 months from August, 2015 to April, 2016 at three hematology-oncology wards of the Namazi Hospital in Shiraz, Iran. Patients>18 years with no documented history of acute kidney injury or chronic kidney disease scheduled to receive VANCOMYCIN for at least 1 week were recruited. Required demographic and clinical data of patients were gathered. Serum, as well as URINE creatinine and URINE KIM-1, were determined at days 0, 3, 5, 7, 10, and 14 of VANCOMYCIN treatment.Results: Thirteen out of the 52 recruited patients (25%) developed NEPHROTOXICITY, with a mean±standard deviation onset of 11.46 ± 7.56 days. Furosemide co-administration (odds ratio=0.126, 95% confidence interval=0.023-0.694, P=0.017) was significantly associated with VANCOMYCIN NEPHROTOXICITY. VANCOMYCIN NEPHROTOXICITY resolved spontaneously in about two-fifths (38.46%) of the affected individuals. Mortality (P=1) and duration of hospitalization (P=0.175) were comparable between patients with and without NEPHROTOXICITY. URINE KIM-1 increased during VANCOMYCIN treatment, but its mean values did not differ significantly within (P= 0.070) or between (P=0.179) patients with and without NEPHROTOXICITY. URINE KIM-1 accuracy in detecting VANCOMYCIN NEPHROTOXICITY was significantly lower than that of serum creatinine at days 5, 7, and 10 of treatment.Conclusions: VANCOMYCIN NEPHROTOXICITY is common but usually reversible and has readily manageable adverse effect. URINE KIM-1 was not more accurate than serum or URINE creatinine in detecting VANCOMYCIN NEPHROTOXICITY in our study population.

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    APA: Copy

    KARIMZADEH, IMAN, HAGHIGHATI, GHAZALEH, RAMZI, MANI, SAGHEB, MOHAMMAD MAHDI, & ZOMORODIAN, KAMIAR. (2017). ASSESSING THE EPIDEMIOLOGY OF NEPHROTOXICITY AND THE ROLE OF URINARY KIDNEY INJURY MOLECULE 1 AS A BIOMARKER OF RENAL FUNCTION IN HEMATOLOGIC-ONCOLOGIC PATIENTS UNDER VANCOMYCIN TREATMENT IN SHIRAZ, IRAN. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(3), 0-0. SID. https://sid.ir/paper/293359/en

    Vancouver: Copy

    KARIMZADEH IMAN, HAGHIGHATI GHAZALEH, RAMZI MANI, SAGHEB MOHAMMAD MAHDI, ZOMORODIAN KAMIAR. ASSESSING THE EPIDEMIOLOGY OF NEPHROTOXICITY AND THE ROLE OF URINARY KIDNEY INJURY MOLECULE 1 AS A BIOMARKER OF RENAL FUNCTION IN HEMATOLOGIC-ONCOLOGIC PATIENTS UNDER VANCOMYCIN TREATMENT IN SHIRAZ, IRAN. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(3):0-0. Available from: https://sid.ir/paper/293359/en

    IEEE: Copy

    IMAN KARIMZADEH, GHAZALEH HAGHIGHATI, MANI RAMZI, MOHAMMAD MAHDI SAGHEB, and KAMIAR ZOMORODIAN, “ASSESSING THE EPIDEMIOLOGY OF NEPHROTOXICITY AND THE ROLE OF URINARY KIDNEY INJURY MOLECULE 1 AS A BIOMARKER OF RENAL FUNCTION IN HEMATOLOGIC-ONCOLOGIC PATIENTS UNDER VANCOMYCIN TREATMENT IN SHIRAZ, IRAN,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 3, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293359/en

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