مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

THE EFFECT OF SYNBIOTIC SUPPLEMENTATION ON BODY COMPOSITION AND LIPID PROFILE IN PATIENTS WITH NAFLD: A RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL STUDY

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Abstract

 Background: Regarding the growing prevalence of non-alcoholic fatty liver disease, concentrating on various strategies for its prevention and management seems necessary.Objectives: This study aimed to assess the effects of synbiotic administration on BODY COMPOSITION and LIPID PROFILE in patients with NAFLD.Methods: Eighty patients with NAFLD participated in this randomized, double-blind, placebo-controlled clinical trial (from March to July 2014) in Iran. Based on AST and ALT as main variables of the study, 34 patients were required in each group (power 80% and a=5%). Considering a 20% sample loss, 80 patients were enrolled. Synbiotic supplement in form of a 500 mg capsule (containing 7 species of probiotic bacteria and Fructooligo saccharides) was administrated to patients in the intervention group and those in the placebo group received 1 placebo capsule daily for 8 weeks. At the baseline and the end of the study, BODY COMPOSITION and LIPID PROFILE were evaluated.Results: A significant reduction was observed in weight (P=0.001), body fat (P=0.02), and TOTAL CHOLESTEROL (P=0.04) within the synbiotic group. On the other hand, WC (P=0.02), TOTAL CHOLESTEROL, and LDL-c (P=0.04 and P=0.001, respectively) were significantly increased in the placebo group. TG, HDL-c, and FBG levels remained statistically unchanged in both groups. Significance between group differences were seen in TOTAL CHOLESTEROL (P=0.01), LDL (P=0.01), weight, WC, and body fat after adjustment for energy intake (P=0.05).Conclusions: Synbiotic supplementation may improve LIPID PROFILE and BODY COMPOSITION in patients with NAFLD and might be useful in prevention of the disease progression.

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    APA: Copy

    ASGHARIAN, ATEFE, MOHAMMADI, VIDA, GHOLI, ZAHRA, ESMAILLZADEH, AHMAD, FEIZI, AWAT, & ASKARI, GHOLAMREZA. (2017). THE EFFECT OF SYNBIOTIC SUPPLEMENTATION ON BODY COMPOSITION AND LIPID PROFILE IN PATIENTS WITH NAFLD: A RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(4), 0-0. SID. https://sid.ir/paper/293374/en

    Vancouver: Copy

    ASGHARIAN ATEFE, MOHAMMADI VIDA, GHOLI ZAHRA, ESMAILLZADEH AHMAD, FEIZI AWAT, ASKARI GHOLAMREZA. THE EFFECT OF SYNBIOTIC SUPPLEMENTATION ON BODY COMPOSITION AND LIPID PROFILE IN PATIENTS WITH NAFLD: A RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(4):0-0. Available from: https://sid.ir/paper/293374/en

    IEEE: Copy

    ATEFE ASGHARIAN, VIDA MOHAMMADI, ZAHRA GHOLI, AHMAD ESMAILLZADEH, AWAT FEIZI, and GHOLAMREZA ASKARI, “THE EFFECT OF SYNBIOTIC SUPPLEMENTATION ON BODY COMPOSITION AND LIPID PROFILE IN PATIENTS WITH NAFLD: A RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL STUDY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 4, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293374/en

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