مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

RECTAL DICLOFENAC VERSUS RECTAL PARACETAMOL: COMPARISON OF ANTIPYRETIC EFFECTIVENESS IN CHILDREN

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Abstract

 Background: FEVER is the most common complaint in pediatric medicine and its treatment is recommended in some situations. PARACETAMOL is the most common antipyretic drug, which has serious side effects such as toxicity along with its positive effects. DICLOFENAC is one of the strongest non-steroidal anti-inflammatory (NSAID) drugs, which has received little attention as an antipyretic drug.Objectives: This study was designed to compare the antipyretic effectiveness of the rectal form of PARACETAMOL and DICLOFENAC.Patients and Methods: This double-blind controlled clinical trial was conducted on 80 children aged six months to six years old. One group was treated with rectal PARACETAMOL suppositories at 15 mg/kg dose and the other group received DICLOFENAC at 1 mg/kg by RECTAL ADMINISTRATION (n=40). Rectal temperature was measured before and one hour after the intervention. Temperature changes in the two groups were compared.Results: The average rectal temperature in the PARACETAMOL group was 39.6±1.13oC, and 39.82±1.07oC in the DICLOFENAC group (P=0.37). The average rectal temperature, one hour after the intervention, in the PARACETAMOL and the DICLOFENAC group was 38.39±0.89oC and 38.95±1.09oC, respectively (P=0.02). Average temperature changes were 0.65±0.17oC in the PARACETAMOL group and 1.73±0.69oC in the DICLOFENAC group (P<0.001).Conclusions: In the first one hour, DICLOFENAC suppository is able to control the FEVER more efficient than PARACETAMOL suppositories.

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    APA: Copy

    SHARIF, MOHAMMAD REZA, HAJI REZAEI, MOSTAFA, AALINEZHAD, MARZIEH, SARAMI, GOLBAHAREH, & RANGRAZ, MASOUD. (2016). RECTAL DICLOFENAC VERSUS RECTAL PARACETAMOL: COMPARISON OF ANTIPYRETIC EFFECTIVENESS IN CHILDREN. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(1), 0-0. SID. https://sid.ir/paper/293403/en

    Vancouver: Copy

    SHARIF MOHAMMAD REZA, HAJI REZAEI MOSTAFA, AALINEZHAD MARZIEH, SARAMI GOLBAHAREH, RANGRAZ MASOUD. RECTAL DICLOFENAC VERSUS RECTAL PARACETAMOL: COMPARISON OF ANTIPYRETIC EFFECTIVENESS IN CHILDREN. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(1):0-0. Available from: https://sid.ir/paper/293403/en

    IEEE: Copy

    MOHAMMAD REZA SHARIF, MOSTAFA HAJI REZAEI, MARZIEH AALINEZHAD, GOLBAHAREH SARAMI, and MASOUD RANGRAZ, “RECTAL DICLOFENAC VERSUS RECTAL PARACETAMOL: COMPARISON OF ANTIPYRETIC EFFECTIVENESS IN CHILDREN,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293403/en

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