DOES ENDURANCE TRAINING COMPENSATE FOR NEUROTROPHIN DEFICIENCY FOLLOWING DIABETIC NEUROPATHY?

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ESLAMI RASOUL; GHARAKHANLOU REZA; KAZEMI ABDOLREZA; DAKHILI AMIRBAHADOR; SORKHKAMANZADEH GHAZALEH; SHEIKHY AYOB

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:10 Page(s): 0-0

Download Full-Text

View:

381

Download:

183

Cites:

Information Journal Paper

Title

DOES ENDURANCE TRAINING COMPENSATE FOR NEUROTROPHIN DEFICIENCY FOLLOWING DIABETIC NEUROPATHY?

Author(s)

Keywords

DIABETIC NEUROPATHY

BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF)

NERVE GROWTH FACTOR (NGF)

ENDURANCE TRAINING

Abstract

Background: A lack of neurotrophic support is believed to contribute to the development of DIABETIC NEUROPATHY. On the other hand, neurotrophins have consistently been shown to increase in the central and peripheral nervous system following exercise, but the effects of exercise intervention on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in DIABETIC NEUROPATHY are not understood.Objectives: This experimental study was designed and carried out at the Tarbiat Modares university (TMU) in Tehran, Iran, to investigate the hypothesis that increased activity as ENDURANCE TRAINING can help to increase the endogenous expression of neurotrophins in diabetic rats.Methods: This was an experimental study with 22 factorial plans performed at TMU in Iran. Sampling was accidental and 28 adult male Wistar rats in the body mass range of 326.3±8.4 g comprised the sample, with each rat randomly assigned to four groups: diabetic control (DC), diabetic training (DT), healthy control (HC), and healthy training (HT). To induce DIABETIC NEUROPATHY, after 12 hours of food deprivation, an intraperitoneal injection of streptozotocin (STZ) solution (45 mg/Kg) method was used. Two weeks after STZ injection, the ENDURANCE TRAINING protocol was performed for 6 weeks; 24 hours after the last training session, the rats were sacrificed. Real-time PCR was used for BDNF and NGF expression.Results: The data indicate that diabetes decreases BDNF and NGF expression in sensory (92%, P=0.01; 90%, P=0.038, respectively) and motor (93%, P=0.05; 60%, P=0.029, respectively) roots. However, NGF mRNA levels in the DT group were significantly higher than in the HC group ((7.1-fold), P=0.01; (2.2-fold), P=0.001, respectively, for sensory and motor roots), but this was not shown for BDNF. In addition, ENDURANCE TRAINING can increase NGF expression in healthy rats ((7.4-fold), P=0.01; (3.8-fold), P=0.001, respectively, for sensory and motor roots).Conclusions: This study shows that BDNF and NGF expression decreases in DIABETIC NEUROPATHY. However, this decrease can be reversed through ENDURANCE TRAINING. These results also indicate that ENDURANCE TRAINING may have a potential role in compensating for neurotrophin deficiency following DIABETIC NEUROPATHY.

Cites

No record.

References

No record.

Cite

APA: Copy

ESLAMI, RASOUL, GHARAKHANLOU, REZA, KAZEMI, ABDOLREZA, DAKHILI, AMIRBAHADOR, SORKHKAMANZADEH, GHAZALEH, & SHEIKHY, AYOB. (2016). DOES ENDURANCE TRAINING COMPENSATE FOR NEUROTROPHIN DEFICIENCY FOLLOWING DIABETIC NEUROPATHY?. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(10), 0-0. SID. https://sid.ir/paper/293444/en

Vancouver: Copy

ESLAMI RASOUL, GHARAKHANLOU REZA, KAZEMI ABDOLREZA, DAKHILI AMIRBAHADOR, SORKHKAMANZADEH GHAZALEH, SHEIKHY AYOB. DOES ENDURANCE TRAINING COMPENSATE FOR NEUROTROPHIN DEFICIENCY FOLLOWING DIABETIC NEUROPATHY?. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(10):0-0. Available from: https://sid.ir/paper/293444/en

IEEE: Copy

RASOUL ESLAMI, REZA GHARAKHANLOU, ABDOLREZA KAZEMI, AMIRBAHADOR DAKHILI, GHAZALEH SORKHKAMANZADEH, and AYOB SHEIKHY, “DOES ENDURANCE TRAINING COMPENSATE FOR NEUROTROPHIN DEFICIENCY FOLLOWING DIABETIC NEUROPATHY?,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 10, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293444/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops