ANGIOTENSIN II TYPE 1 RECEPTOR GENE A1166C POLYMORPHISM WAS NOT ASSOCIATED WITH ACUTE CORONARY SYNDROME IN AN IRANIAN POPULATION

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DELSHAD NAVID; GHAYOUR MOBARHAN MAJID; MIRZAEI HAMED; RAZAVI AZARKHIAVI KAMAL; MOOHEBATI MOHSEN; HASSANY MITRA; KASAIAN JAMAL; ETEMADZADEH MOHAMMAD REZA; ALAVI MARYAM SADAT; BEHRAVAN JAVAD

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:11 Page(s): 0-0

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Title

ANGIOTENSIN II TYPE 1 RECEPTOR GENE A1166C POLYMORPHISM WAS NOT ASSOCIATED WITH ACUTE CORONARY SYNDROME IN AN IRANIAN POPULATION

Author(s)

Keywords

ACUTE CORONARY SYNDROME

ANGIOTENSIN II TYPE 1 RECEPTOR

GENE POLYMORPHISMS

GENOTYPE FREQUENCY

AT1R A1166C

Abstract

Background: There are very limited data for Iranian populations on the predisposing genetic factors for ACUTE CORONARY SYNDROME (ACS).Objectives: The objective of the present study was to investigate the association of the ANGIOTENSIN II TYPE 1 RECEPTOR (AT1R) gene polymorphism and ACS in an Iranian population.Patients and Methods: This cross-sectional study was conducted among 263 subjects (97 men and 166 women). Patients (n=128) aged 30 - 80 years with chest pain were recruited from the emergency department of Ghaem Hospital (Mashhad, Iran). A 12-lead electrocardiograph plus creatine kinase MB (CK-MB) levels were used as the basis for the diagnosis of myocardial ischemia. The control group was selected from age-matched healthy subjects (n=135). Non-enzymatic kits were used for extraction of DNA from blood samples. Polymerase chain reaction (PCR) was performed to amplify the DNA fragments. For restriction fragment length polymorphism (RFLP) determination, the DdeI enzyme was used to digest the amplified DNA fragments. Statistical analyses were performed using SPSS version 13.0.Results: There was no statistical difference in the GENOTYPE FREQUENCY of patients and healthy subjects with regard to age and gender (P>0.05).Conclusions: The AT1R A1166C polymorphism appeared not to be associated with the presence of ACS in the population studied.

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References

RELATIONSHIP OF RISK FACTORS AND ST SEGMENT CHANGES WITH SYMPTOMS OF ACUTE CORONARY SYNDROME

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APA: Copy

DELSHAD, NAVID, GHAYOUR MOBARHAN, MAJID, MIRZAEI, HAMED, RAZAVI AZARKHIAVI, KAMAL, MOOHEBATI, MOHSEN, HASSANY, MITRA, KASAIAN, JAMAL, ETEMADZADEH, MOHAMMAD REZA, ALAVI, MARYAM SADAT, & BEHRAVAN, JAVAD. (2016). ANGIOTENSIN II TYPE 1 RECEPTOR GENE A1166C POLYMORPHISM WAS NOT ASSOCIATED WITH ACUTE CORONARY SYNDROME IN AN IRANIAN POPULATION. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(11), 0-0. SID. https://sid.ir/paper/293462/en

Vancouver: Copy

DELSHAD NAVID, GHAYOUR MOBARHAN MAJID, MIRZAEI HAMED, RAZAVI AZARKHIAVI KAMAL, MOOHEBATI MOHSEN, HASSANY MITRA, KASAIAN JAMAL, ETEMADZADEH MOHAMMAD REZA, ALAVI MARYAM SADAT, BEHRAVAN JAVAD. ANGIOTENSIN II TYPE 1 RECEPTOR GENE A1166C POLYMORPHISM WAS NOT ASSOCIATED WITH ACUTE CORONARY SYNDROME IN AN IRANIAN POPULATION. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(11):0-0. Available from: https://sid.ir/paper/293462/en

IEEE: Copy

NAVID DELSHAD, MAJID GHAYOUR MOBARHAN, HAMED MIRZAEI, KAMAL RAZAVI AZARKHIAVI, MOHSEN MOOHEBATI, MITRA HASSANY, JAMAL KASAIAN, MOHAMMAD REZA ETEMADZADEH, MARYAM SADAT ALAVI, and JAVAD BEHRAVAN, “ANGIOTENSIN II TYPE 1 RECEPTOR GENE A1166C POLYMORPHISM WAS NOT ASSOCIATED WITH ACUTE CORONARY SYNDROME IN AN IRANIAN POPULATION,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 11, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293462/en

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