RISK FACTORS OF RHEUMATOID ARTHRITIS DEVELOPMENT AMONG FEMALES IN NORTH-WEST OF IRAN: A CASE-CONTROL STUDY

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GHAMARZAD SHISHAVAN NEDA; PIROUZPANAH SAEED; HAJIALILO MEHRZAD; KHABBAZI ALIREZA; JAFARPOUR FARNAZ; MIRTAHERI ELHAM; FARRIN NAZILA; EBRAHIMZADEH SIMA; BABAN NAVID; Shakiba Zahra; Ghahremanzadeh Kazem

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:12 Page(s): 0-0

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Title

RISK FACTORS OF RHEUMATOID ARTHRITIS DEVELOPMENT AMONG FEMALES IN NORTH-WEST OF IRAN: A CASE-CONTROL STUDY

Author(s)

Keywords

RHEUMATOID ARTHRITIS

BREAST-FEEDING

REPRODUCTIVE HISTORY

ORAL CONTRACEPTIVES

Abstract

Background: Given the high prevalence of RHEUMATOID ARTHRITIS (RA) in females of reproductive ages, it seems that hormonal factors might be important in RA pathogenesis.Objectives: The current study aimed to investigate the association between females’ reproductive factors occurring prior to the onset of RHEUMATOID ARTHRITIS and the risk of RA development.Methods: This case-control study was conducted on 231 patients with RA and 238 controls among females aged 26 - 64 years old from the North-West of Iran. The adjusted risk of RA was assessed using multivariate logistic regression models.Results: Females³14 years old at menarche, were more likely to be at risk of RA (OR=1.69; 95%CI: 1.08 - 2.64). Advanced maternal age at first delivery (OR=1.91; 95%CI: 1.21 - 3.26) and having abortion (OR=1.97; 95%CI: 1.23 - 2.99) significantly increased the risk of RA. Post-menopausal status increased the risk of developing RA (OR=2.97; 95%CI: 1.98 - 4.46). Longer duration of BREAST-FEEDING was determined as significant protective variable for RA (P<0.05). Subjects with ORAL CONTRACEPTIVES (OCs) use (OR=0.36; 95% CI: 0.20 - 0.64), parity (OR=0.20; 95%CI: 0.06 - 0.70) or large number of children tended to show rather more reduced risk of RA.Conclusions: The risk of RA increased with delayed menarche, advanced maternal age at first delivery and early age at menopause. However, longer duration of BREAST-FEEDING, parity, large number of children and consumption of OCs were found as protective independent variables against RA.

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APA: Copy

GHAMARZAD SHISHAVAN, NEDA, PIROUZPANAH, SAEED, HAJIALILO, MEHRZAD, KHABBAZI, ALIREZA, JAFARPOUR, FARNAZ, MIRTAHERI, ELHAM, FARRIN, NAZILA, EBRAHIMZADEH, SIMA, BABAN, NAVID, Shakiba, Zahra, & Ghahremanzadeh, Kazem. (2016). RISK FACTORS OF RHEUMATOID ARTHRITIS DEVELOPMENT AMONG FEMALES IN NORTH-WEST OF IRAN: A CASE-CONTROL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(12), 0-0. SID. https://sid.ir/paper/293474/en

Vancouver: Copy

GHAMARZAD SHISHAVAN NEDA, PIROUZPANAH SAEED, HAJIALILO MEHRZAD, KHABBAZI ALIREZA, JAFARPOUR FARNAZ, MIRTAHERI ELHAM, FARRIN NAZILA, EBRAHIMZADEH SIMA, BABAN NAVID, Shakiba Zahra, Ghahremanzadeh Kazem. RISK FACTORS OF RHEUMATOID ARTHRITIS DEVELOPMENT AMONG FEMALES IN NORTH-WEST OF IRAN: A CASE-CONTROL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(12):0-0. Available from: https://sid.ir/paper/293474/en

IEEE: Copy

NEDA GHAMARZAD SHISHAVAN, SAEED PIROUZPANAH, MEHRZAD HAJIALILO, ALIREZA KHABBAZI, FARNAZ JAFARPOUR, ELHAM MIRTAHERI, NAZILA FARRIN, SIMA EBRAHIMZADEH, NAVID BABAN, Zahra Shakiba, and Kazem Ghahremanzadeh, “RISK FACTORS OF RHEUMATOID ARTHRITIS DEVELOPMENT AMONG FEMALES IN NORTH-WEST OF IRAN: A CASE-CONTROL STUDY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 12, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293474/en

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