COMPARING ZONISAMIDE WITH SODIUM VALPROATE IN THE MANAGEMENT OF MIGRAINE HEADACHES: DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL OF EFFICACY AND SAFETY

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ASSARZADEGAN FARHAD; TABESH HANIF; HOSSEINI ZIJOUD SEYED MOSTAFA; BEALE ANDREW DAVID; SHOGHLI ARYA; GHAFOORI YAZDI MAHMOOD; MANSOURI BEHNAM; HESAMI OMID; BELADI MOGHADAM NAHID; DELAVAR KASMAEI HOSEIN

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:9 Page(s): 0-0

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Title

COMPARING ZONISAMIDE WITH SODIUM VALPROATE IN THE MANAGEMENT OF MIGRAINE HEADACHES: DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL OF EFFICACY AND SAFETY

Author(s)

Keywords

ZONISAMIDE

SODIUM VALPROATE

MIGRAINE HEADACHES

RCT

Abstract

Background: Migraine is one of the most debilitating medical conditions and has a high socioeconomic burden. As conventional therapeutic methods do not entirely alleviate the symptoms, new alternatives are being considered.Objectives: This study evaluates the efficacy and safety of ZONISAMIDE compared with SODIUM VALPROATE in the management of MIGRAINE HEADACHES.Patients and Methods: In the current double-blind, parallel, randomized, controlled trial, 96 patients with a migraine diagnosis based on the international headache society (HIS) criteria were selected. They were divided randomly into two groups; the case group was given ZONISAMIDE, and SODIUM VALPROATE was given to a control group. In addition to the side effects of the drugs, the severity, duration, and frequency of migraine attacks were evaluated at baseline and at three months.Results: The 96 selected patients were divided randomly into two treatment groups (ZONISAMIDE n=48, SODIUM VALPROATE n=48). Seven patients were excluded from analysis because of early dropout, leaving 89 (n=45; n=44) patients for analysis. While using ZONISAMIDE, six (13%) patients complained of fatigue, and two (4%) patients encountered noticeable appetite and weight loss. In the control group, five (11%) patients reported dizziness, and four (9%) patients faced obvious appetite and weight gain. Both drugs were considerably efficient in reducing further attacks. There was no statistically significant correlation between frequency or severity of migraine attacks and the drug used for treatment in three months of follow-up.Conclusions: Both medications are effective in reducing migraine attacks. It will be important to consider the drugs’ adverse effects and availability and patients’ medical and socioeconomic condition to select the appropriate treatment.

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TERATOGENIC EFFECTS OF SOME FACTORS ON THE HUMAN FETUS: A REVIEW STUDY

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APA: Copy

ASSARZADEGAN, FARHAD, TABESH, HANIF, HOSSEINI ZIJOUD, SEYED MOSTAFA, BEALE, ANDREW DAVID, SHOGHLI, ARYA, GHAFOORI YAZDI, MAHMOOD, MANSOURI, BEHNAM, HESAMI, OMID, BELADI MOGHADAM, NAHID, & DELAVAR KASMAEI, HOSEIN. (2016). COMPARING ZONISAMIDE WITH SODIUM VALPROATE IN THE MANAGEMENT OF MIGRAINE HEADACHES: DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL OF EFFICACY AND SAFETY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(9), 0-0. SID. https://sid.ir/paper/293507/en

Vancouver: Copy

ASSARZADEGAN FARHAD, TABESH HANIF, HOSSEINI ZIJOUD SEYED MOSTAFA, BEALE ANDREW DAVID, SHOGHLI ARYA, GHAFOORI YAZDI MAHMOOD, MANSOURI BEHNAM, HESAMI OMID, BELADI MOGHADAM NAHID, DELAVAR KASMAEI HOSEIN. COMPARING ZONISAMIDE WITH SODIUM VALPROATE IN THE MANAGEMENT OF MIGRAINE HEADACHES: DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL OF EFFICACY AND SAFETY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(9):0-0. Available from: https://sid.ir/paper/293507/en

IEEE: Copy

FARHAD ASSARZADEGAN, HANIF TABESH, SEYED MOSTAFA HOSSEINI ZIJOUD, ANDREW DAVID BEALE, ARYA SHOGHLI, MAHMOOD GHAFOORI YAZDI, BEHNAM MANSOURI, OMID HESAMI, NAHID BELADI MOGHADAM, and HOSEIN DELAVAR KASMAEI, “COMPARING ZONISAMIDE WITH SODIUM VALPROATE IN THE MANAGEMENT OF MIGRAINE HEADACHES: DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL OF EFFICACY AND SAFETY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 9, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293507/en

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