THE ASSOCIATION BETWEEN C424C/A POLYMORPHISM WITHIN THE IL-25 GENE AND MULTIPLE SCLEROSIS

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ZARE LIDA; SHEIKH FATHOLLAHI MAHMOOD; KAZEMI ARABABADI MOHAMMAD; SHAMSIZADEH ALI; DANESHPAJOUH BEHNAM; ZAINODINI NAHID; ALLAHTAVAKOLI MOHAMMAD

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:9 Page(s): 0-0

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Title

THE ASSOCIATION BETWEEN C424C/A POLYMORPHISM WITHIN THE IL-25 GENE AND MULTIPLE SCLEROSIS

Author(s)

Keywords

MULTIPLE SCLEROSIS

POLYMORPHISM

GENETIC

CCL25

Abstract

Background: MULTIPLE SCLEROSIS (MS) is a common autoimmune system disease which affects the central nervous system. It has been documented that interleukin-25 (IL-25) plays key roles in suppressing Th1 responses, which is increased during MS.Objectives: The aim of this study was to investigate the c424C/A POLYMORPHISM within the IL-25 gene in MS patients in comparison to healthy controls.Patients and Methods: In this case-control study, 74 patients with MS and 75 healthy controls were selected. Polymerase Chain Reaction-Restriction Fragment Length POLYMORPHISM (PCR-RFLP) was used in order to determine c424C/A POLYMORPHISM within the IL-25 gene.Results: The results showed that there was no statistical significant difference in distribution of genotype (AA, AC and CC) and allele (A and C) frequencies between MS patients and healthy controls (P=0.901 and P=0.728, respectively).Conclusions: In conclusion, it appears that the c424C/A POLYMORPHISM within the IL-25 gene has no significant relationship with MS, and this POLYMORPHISM is probably not associated with MS complications, its onset and gender distribution.

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APA: Copy

ZARE, LIDA, SHEIKH FATHOLLAHI, MAHMOOD, KAZEMI ARABABADI, MOHAMMAD, SHAMSIZADEH, ALI, DANESHPAJOUH, BEHNAM, ZAINODINI, NAHID, & ALLAHTAVAKOLI, MOHAMMAD. (2016). THE ASSOCIATION BETWEEN C424C/A POLYMORPHISM WITHIN THE IL-25 GENE AND MULTIPLE SCLEROSIS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(9), 0-0. SID. https://sid.ir/paper/293509/en

Vancouver: Copy

ZARE LIDA, SHEIKH FATHOLLAHI MAHMOOD, KAZEMI ARABABADI MOHAMMAD, SHAMSIZADEH ALI, DANESHPAJOUH BEHNAM, ZAINODINI NAHID, ALLAHTAVAKOLI MOHAMMAD. THE ASSOCIATION BETWEEN C424C/A POLYMORPHISM WITHIN THE IL-25 GENE AND MULTIPLE SCLEROSIS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(9):0-0. Available from: https://sid.ir/paper/293509/en

IEEE: Copy

LIDA ZARE, MAHMOOD SHEIKH FATHOLLAHI, MOHAMMAD KAZEMI ARABABADI, ALI SHAMSIZADEH, BEHNAM DANESHPAJOUH, NAHID ZAINODINI, and MOHAMMAD ALLAHTAVAKOLI, “THE ASSOCIATION BETWEEN C424C/A POLYMORPHISM WITHIN THE IL-25 GENE AND MULTIPLE SCLEROSIS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 9, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293509/en

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