EFFECTS OF SECOND AND THIRD GENERATION ORAL CONTRACEPTIVES ON LIPID AND CARBOHYDRATE METABOLISM IN OVERWEIGHT AND OBESEWOMEN: A RANDOMIZED TRIPLE-BLIND CONTROLLED TRIAL

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SHAHNAZI MAHNAZ; FARSHBAF KHALILI AZIZEH; POURZEINALI BEILANKOUH SAMIRA; SADRIMEHR FARNAZ

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:9 Page(s): 0-0

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Title

EFFECTS OF SECOND AND THIRD GENERATION ORAL CONTRACEPTIVES ON LIPID AND CARBOHYDRATE METABOLISM IN OVERWEIGHT AND OBESEWOMEN: A RANDOMIZED TRIPLE-BLIND CONTROLLED TRIAL

Author(s)

SHAHNAZI MAHNAZ | FARSHBAF KHALILI AZIZEH | POURZEINALI BEILANKOUH SAMIRA | SADRIMEHR FARNAZ | Issue Writer Certificate

Keywords

LEVONORGESTREL

DESOGESTREL

OVERWEIGHT

OBESITY

LIPID METABOLISM

CARBOHYDRATE METABOLISM

Abstract

Background: Combined oral contraceptives (COCs) have not been shown to have major effects on lipid and CARBOHYDRATE METABOLISM in normal-weight women. However, we have limited information about the effects on women at high risk for cardiovascular disease and diabetes due to being OVERWEIGHT and obese.Objectives: To evaluate the effects of second and third generation contraceptive pills on lipid and CARBOHYDRATE METABOLISM in OVERWEIGHT and obese women.Patients and Methods: This triple-blind controlled trial was performed on 137 healthy women aged 18 - 40 years with a body mass index of 25-34.9 (kg/m2) who were referred to health centers in Tabriz, Iran from 2014 to 2015. The women were randomly divided into groups who were to take 30 mcg ethinyl estradiol/150 mcg LEVONORGESTREL (EE/LGN) (n=69) or 30 mcg ethinyl estradiol/150 mcg DESOGESTREL (EE/DSG) (n=68) with an allocation ratio of 1: 1 for three cycles. As primary outcomes, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and fasting plasma glucose (FPG) were assessed; total cholesterol (TC), triglycerides (TG), and 2-hour plasma glucose in the 75-g oral glucose tolerance test (2-hour 75-g OGTT) were assessed as secondary outcomes.Results: The differences in lipid and carbohydrate parameters were not significant between the two groups, except for HDL-C (Adjusted MD ( CI95%) =7.00 (2.98 to 11.02)). HDL-C decreased with EE/LGN (P=0.016) and increased with EE/DSG (P=0.004). LDL-C and TC increased in both groups, whereas TG increased only with EE/DSG (P<0.05). Compared with the baseline, FPG levels did not differ significantly in both groups, but EE/DSG increased 2-hour 75-g OGTT (P=0.010).Conclusions: We observed no significant differences between the two groups in lipid and CARBOHYDRATE METABOLISM, except for HDLC.Considering the importance of OVERWEIGHT and obese women’s health, studies with longer follow-up periods are recommended in this respect.

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APA: Copy

SHAHNAZI, MAHNAZ, FARSHBAF KHALILI, AZIZEH, POURZEINALI BEILANKOUH, SAMIRA, & SADRIMEHR, FARNAZ. (2016). EFFECTS OF SECOND AND THIRD GENERATION ORAL CONTRACEPTIVES ON LIPID AND CARBOHYDRATE METABOLISM IN OVERWEIGHT AND OBESEWOMEN: A RANDOMIZED TRIPLE-BLIND CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(9), 0-0. SID. https://sid.ir/paper/293526/en

Vancouver: Copy

SHAHNAZI MAHNAZ, FARSHBAF KHALILI AZIZEH, POURZEINALI BEILANKOUH SAMIRA, SADRIMEHR FARNAZ. EFFECTS OF SECOND AND THIRD GENERATION ORAL CONTRACEPTIVES ON LIPID AND CARBOHYDRATE METABOLISM IN OVERWEIGHT AND OBESEWOMEN: A RANDOMIZED TRIPLE-BLIND CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(9):0-0. Available from: https://sid.ir/paper/293526/en

IEEE: Copy

MAHNAZ SHAHNAZI, AZIZEH FARSHBAF KHALILI, SAMIRA POURZEINALI BEILANKOUH, and FARNAZ SADRIMEHR, “EFFECTS OF SECOND AND THIRD GENERATION ORAL CONTRACEPTIVES ON LIPID AND CARBOHYDRATE METABOLISM IN OVERWEIGHT AND OBESEWOMEN: A RANDOMIZED TRIPLE-BLIND CONTROLLED TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 9, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293526/en

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