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Information Journal Paper

Title

THE EFFECT OF ALPHA-LIPOIC ACID ON LIVER FUNCTION AND METABOLICMARKERS IN OBESE PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE: ADOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL

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Abstract

 Background: INSULIN RESISTANCE has a pivotal role in the occurrence of impaired GLUCOSE tolerance and DYSLIPIDEMIA in patientswith NON-ALCOHOLIC FATTY LIVER Disease (NAFLD). There is evidence of possible beneficial effects of ALPHA-LIPOIC ACID (ALA) on insulinresistance and metabolic disorders. Objectives: This studyaimedatexaminingthe effects of ALAsupplementationonliver enzymes, insulin sensitivity, GLUCOSE markers, and lipid profile in obese patients with NAFLD. Methods: In this double-blind placebo-controlled randomized clinical trial, 50 obese patients with NAFLD were randomly allocatedto “ ALA group” (received 1200 mg ALA as two capsules per day) or “ Placebo group” (received placebo containing cornstarch as twocapsules per day) for 12 weeks. Anthropometric measures, dietary intakes, liver enzymes as well as GLUCOSE markers and lipid profilewere assessed at baseline and after 12 weeks of intervention. Results: Forty-five patients completed the study (ALA group = 23; placebo group = 22). Liver enzymes were not significantly alteredby the intervention group. ALPHA LIPOIC ACID supplementation led to a significant attenuation in serum levels of insulin (13. 4 5. 4vs. 18. 1  8. 6; P = 0. 019) and triglyceride (146. 9  60. 6 vs. 186. 3  54. 2; P = 0. 037) in comparison with the placebo group, yet didnot affect other lipid profile parameters, Fasting Serum GLUCOSE (FSG) and -cell function index (HOMA-B) in patients with NAFLD. furthermore, quantitative insulin sensitivity check index (QUICKI) increased significantly in the ALA group compared to the placebo(0. 329 0. 025 versus 0. 317 0. 020; P = 0. 033). Conclusions: Patients with NAFLD may benefit from ALA supplementation, at least partially through augmented insulin sensitivityand improvement of lipid profile.

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    APA: Copy

    AMIRKHIZI, FARSHAD, HAMEDI SHAHRAKI, SOUDABEH, HOSSEINPOUR ARJMAND, SONYA, & EBRAHIMI MAMEGHANI, MEHRANGIZ. (2018). THE EFFECT OF ALPHA-LIPOIC ACID ON LIVER FUNCTION AND METABOLICMARKERS IN OBESE PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE: ADOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(3), 0-0. SID. https://sid.ir/paper/293714/en

    Vancouver: Copy

    AMIRKHIZI FARSHAD, HAMEDI SHAHRAKI SOUDABEH, HOSSEINPOUR ARJMAND SONYA, EBRAHIMI MAMEGHANI MEHRANGIZ. THE EFFECT OF ALPHA-LIPOIC ACID ON LIVER FUNCTION AND METABOLICMARKERS IN OBESE PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE: ADOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(3):0-0. Available from: https://sid.ir/paper/293714/en

    IEEE: Copy

    FARSHAD AMIRKHIZI, SOUDABEH HAMEDI SHAHRAKI, SONYA HOSSEINPOUR ARJMAND, and MEHRANGIZ EBRAHIMI MAMEGHANI, “THE EFFECT OF ALPHA-LIPOIC ACID ON LIVER FUNCTION AND METABOLICMARKERS IN OBESE PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE: ADOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 3, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293714/en

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