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Title

CLINICAL OUTCOMES AND ELECTROLYTE BALANCE FACTORS IN COMPLEX CARDIACOPERATIONS IN ADULTS; DEL NIDO® VERSUS CUSTODIOL® CARDIOPLEGIASOLUTIONS: A RANDOMIZED CONTROLLED CLINICAL TRIAL

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Abstract

 Background: CARDIOPLEGIA is used for protection of myocardium during CARDIAC operations. DEL NIDO® (DN) and Custodiol® CARDIOPLEGIA(CC) SOLUTIONS are used for prolonged protection of the myocardium during CARDIOPULMONARY bypass (CPB). Custodiol® CARDIOPLEGIA solution is gaining popularity for myocardial protection during CARDIOPULMONARY bypass. Objectives: This study aimed to compare the effects of Custodiol® with another CARDIOPLEGIA solution, DEL NIDO® , on myocardialprotection during CARDIOPULMONARY bypass. Methods: In a randomized controlled clinical trial, forty patients were randomly allocated to DelNido® and Custodiol® (CC) groups. Patients in both groups received a standard ANESTHESIA protocol. For CARDIOPLEGIA, in the DN group, the DEL NIDO® solution wasadministered every 90 minutes by the antegrade route. In the CC, group, the Custodiol® solution was administered in the same wayat the beginning of the CARDIOPLEGIA. Demographic information, blood chemistry parameters and other related perioperative andpostoperative clinical indices were recorded. Results: Frequency of female patients was 14/21 (66. 66%) in the DN and 12/19 (63. 15%) in the CC group (P = 0. 816), age was 57. 14 12. 48years versus 59. 47 11. 96 years (P = 0. 551), weight was 70. 95 9. 56 kilograms versus 69. 63 7. 64 kilograms (P = 0. 635), CPB time was103. 19 23. 43 minutes versus 97. 36 16. 7 minutes (P = 0. 376), and cross-clamp time was 73. 76 19. 66 minutes versus 83. 95 16. 14minutes (P = 0. 083). Blood chemistry and blood gas analysis revealed a similar trend between the two groups in these parameters (P> 0. 05) except for higher sodium levels after CARDIOPLEGIA (P = 0. 016) and end of CPB (P = 0. 002), potassium levels after CARDIOPLEGIA(P = 0. 029), and bicarbonate anions at the end of bypass (P = 0. 03) in the Custodiol® group. Conclusions: In conclusion, CC and DN offer effective myocardial protection during CARDIOPULMONARY bypass. It is recommendedto restrict the use of CC in patients susceptible to electrolyte disturbances.

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APA: Copy

MEHRABANIAN, MOHAMMAD JAVAD, DEHGHANI FIROOZABADI, MEHDI, AHMADI TAFTI, SEYED HOSSEIN, FOROUZAN NIA, SEYED KHALIL, NAJAFI, ATABAK, MORTAZIAN, MEYSAM, ZERAATIAN NEJAD DAVANI, SAM, SOLTANINIA, HASSAN, GHIASI, ABBAS, GORJIPOUR, FARHAD, & MAHDAVI GORABI, ARMITA. (2018). CLINICAL OUTCOMES AND ELECTROLYTE BALANCE FACTORS IN COMPLEX CARDIACOPERATIONS IN ADULTS; DEL NIDO® VERSUS CUSTODIOL® CARDIOPLEGIASOLUTIONS: A RANDOMIZED CONTROLLED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(4), 0-0. SID. https://sid.ir/paper/293717/en

Vancouver: Copy

MEHRABANIAN MOHAMMAD JAVAD, DEHGHANI FIROOZABADI MEHDI, AHMADI TAFTI SEYED HOSSEIN, FOROUZAN NIA SEYED KHALIL, NAJAFI ATABAK, MORTAZIAN MEYSAM, ZERAATIAN NEJAD DAVANI SAM, SOLTANINIA HASSAN, GHIASI ABBAS, GORJIPOUR FARHAD, MAHDAVI GORABI ARMITA. CLINICAL OUTCOMES AND ELECTROLYTE BALANCE FACTORS IN COMPLEX CARDIACOPERATIONS IN ADULTS; DEL NIDO® VERSUS CUSTODIOL® CARDIOPLEGIASOLUTIONS: A RANDOMIZED CONTROLLED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(4):0-0. Available from: https://sid.ir/paper/293717/en

IEEE: Copy

MOHAMMAD JAVAD MEHRABANIAN, MEHDI DEHGHANI FIROOZABADI, SEYED HOSSEIN AHMADI TAFTI, SEYED KHALIL FOROUZAN NIA, ATABAK NAJAFI, MEYSAM MORTAZIAN, SAM ZERAATIAN NEJAD DAVANI, HASSAN SOLTANINIA, ABBAS GHIASI, FARHAD GORJIPOUR, and ARMITA MAHDAVI GORABI, “CLINICAL OUTCOMES AND ELECTROLYTE BALANCE FACTORS IN COMPLEX CARDIACOPERATIONS IN ADULTS; DEL NIDO® VERSUS CUSTODIOL® CARDIOPLEGIASOLUTIONS: A RANDOMIZED CONTROLLED CLINICAL TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 4, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293717/en

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