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Information Journal Paper

Title

THE EFFECT OF A HOLISTIC CARE PROGRAM ON THE REDUCTION OF IRONOVERLOAD IN PATIENTS WITH BETA-THALASSEMIA MAJOR: A RANDOMIZEDCLINICAL TRIAL

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Abstract

 Background: The increased IRON load is the main problem in BETA-THALASSEMIA major; chelation therapy is used for its counteraction. Non-compliance with IRON chelation therapy leads to certain complications and the economic burden caused by them furtherhighlights the importance of therapies for reducing IRON overload. Administering lower doses of the chelating agent reduces boththe complications faced by the patients and the economic burden on the health system. Objectives and Methods: This randomized clinical trial was conducted to investigate the effect of a HOLISTIC care program (HCP)on the reduction of IRON overload in patients with BETA-THALASSEMIA major referring to the largest center for THALASSEMIA patients inMashhad (Iran). Ninety eligible patients were randomly selected and enrolled in this study from September 2012 to February 2015. The subjects gave their informed consent and were then divided into an intervention (n = 45) and control group (n = 45) throughstratified randomization while taking into account the type of a chelating agent as the confounder. The HCP was conducted asa randomized trial in three parts: 1-individual counseling (4 45-60-min sessions for each patient), 2-group training (4 60-90-min sessions for each patient), and 3-rehabilitation (8 weeks). Of the 500 patients with BETA-THALASSEMIA major, 90 samples wererandomly selected. After they gave their informed consent, the samples were randomly assigned to 2 groups, i. e., an HCP groupand a control group. Before beginning the intervention and 3 months later, the patients’ levels of serum FERRITIN and IRON, totaliron binding capacity or TIBC (to check the IRON load), and hemoglobin or Hb (to prevent hemolysis) were examined and the 6-minute walk test (6MWT) was also performed for assessing their functional ability and to ensure they were able to comply with therehabilitation program. The patients in the control group received routine care only. The pre-and post-intervention evaluations inthe control group were similar to those in the intervention group. Results: Changes in serum IRON and FERRITIN, as well as the6MWTdistance, differed significantly between the test and control groups(P < 0. 05). TIBC and Hb levels, however, showed no significant differences between the two groups (P > 0. 05). The mean changes inserum IRON and FERRITIN, 6MWT, TIBC, and Hb equaled-71. 02 97. 28,-1172. 75 2032. 14, 65. 97 81. 1, 29. 71 80. 95, and 0. 06 1. 75 inthe intervention group and-5. 46 96. 73,-8. 08 998. 56,-33. 97 54. 28, 21. 37 90. 45, and 0. 33 1. 5 in the control group. Conclusions: It seems that any change in the mental and psychological conditions of chronic patients, especially those with THALASSEMIA, improves their self-care behaviors and thereby, their treatment compliance. Based on the results, the HCP was effective inreducing FERRITIN levels in patients with THALASSEMIA major in this study. Therefore, this is program is recommended to be used inthe care of THALASSEMIA patients.

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    APA: Copy

    ARIAN, MAHDIEH, MEMARIAN, ROBABEH, OGHAZIAN, MOHAMMAD BAGHER, VAKILIAN, FARVEH, & BADIEE, ZAHRA. (2018). THE EFFECT OF A HOLISTIC CARE PROGRAM ON THE REDUCTION OF IRONOVERLOAD IN PATIENTS WITH BETA-THALASSEMIA MAJOR: A RANDOMIZEDCLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(4), 0-0. SID. https://sid.ir/paper/293726/en

    Vancouver: Copy

    ARIAN MAHDIEH, MEMARIAN ROBABEH, OGHAZIAN MOHAMMAD BAGHER, VAKILIAN FARVEH, BADIEE ZAHRA. THE EFFECT OF A HOLISTIC CARE PROGRAM ON THE REDUCTION OF IRONOVERLOAD IN PATIENTS WITH BETA-THALASSEMIA MAJOR: A RANDOMIZEDCLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(4):0-0. Available from: https://sid.ir/paper/293726/en

    IEEE: Copy

    MAHDIEH ARIAN, ROBABEH MEMARIAN, MOHAMMAD BAGHER OGHAZIAN, FARVEH VAKILIAN, and ZAHRA BADIEE, “THE EFFECT OF A HOLISTIC CARE PROGRAM ON THE REDUCTION OF IRONOVERLOAD IN PATIENTS WITH BETA-THALASSEMIA MAJOR: A RANDOMIZEDCLINICAL TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 4, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293726/en

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