EFFECTS OF SAFFRON AQUEOUS EXTRACT AND ITS MAIN CONSTITUENT, CROCIN, ON HEALTH-RELATED QUALITY OF LIFE, DEPRESSION, AND SEXUAL DESIRE INCORONARY ARTERY DISEASE PATIENTS: A DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED CLINICAL TRIAL

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Abedimanesh Nasim; OSTADRAHIMI ALIREZA; Bathaie S.Zahra; ABEDIMANESH SAEED; MOTLAGH BEHROOZ; ASGHARI JAFARABADI MOHAMMAD; TABAN SADEGHI MOHAMMAD REZA

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Journal: Iranian Red Crescent Medical Journal Year:2017 | Volume:19 | Issue:9 Page(s): 0-0

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Title

EFFECTS OF SAFFRON AQUEOUS EXTRACT AND ITS MAIN CONSTITUENT, CROCIN, ON HEALTH-RELATED QUALITY OF LIFE, DEPRESSION, AND SEXUAL DESIRE INCORONARY ARTERY DISEASE PATIENTS: A DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED CLINICAL TRIAL

Author(s)

Keywords

SAFFRON

CROCIN

DEPRESSION

QUALITY OF LIFE

CORONARY ARTERY DISEASE

Abstract

Background: DEPRESSION and sexual problems are common in patients with CORONARY ARTERY DISEASE (CAD) and can influence theirquality of life. Objectives: The aim of this study was to compare the efficacy of SAFFRON and its main constituent, CROCIN, in improving mental andsexual health and ultimately QUALITY OF LIFE in CAD patients. Methods: This double-blind, placebo-controlled, randomized clinical trial was carried out during 8 weeks in 3 groups, including1 placebo and 2 intervention groups. The study sample included 58 CAD patients within the age range of 40-65 years, referred toShahid Madani cardiovascular hospital, Tabriz, Iran, from April 2015 to November 2016. The intervention groups received SAFFRONaqueous extract (SAE; 30 mg; n, 20) or CROCIN (30 mg; n, 19). All the groups completed the demographic questionnaire, Beck DEPRESSIONinventory-II (BDI-II), Hulbert index of sexual desire (HISD), and MacNew health-related QUALITY OF LIFE questionnaire. Results: The BDI-II score significantly decreased in the SAE (pre-and post test scores, 26. 10 11. 98 and 21. 05 9. 93, respectively)and CROCIN (pre-and post test scores, 27. 89 8. 46 and 22. 68 8. 01, respectively) groups (P < 0. 001). After adjustments for age, sex, and diagnosis time, similar results were obtained. There was no significant difference between the CROCIN and SAE groups in termsof total BDI-II score at the end of the study (P = 0. 999). SAE and CROCIN had no significant effects on HISD scores (P = 0. 148 and 0. 317, respectively). However, they could significantly improve the total QUALITY OF LIFE and its subscales (P < 0. 001). Conclusions: SAE and CROCIN could improve DEPRESSION and health-related QUALITY OF LIFE in patients with CAD, whereas they had nosignificant effects on sexual desire.

Cites

Review Article: Effects of saffron (Crocus sativus) on sexual dysfunction among men and women: A systematic review and meta-analysis

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APA: Copy

Abedimanesh, Nasim, OSTADRAHIMI, ALIREZA, Bathaie, S.Zahra, ABEDIMANESH, SAEED, MOTLAGH, BEHROOZ, ASGHARI JAFARABADI, MOHAMMAD, & TABAN SADEGHI, MOHAMMAD REZA. (2017). EFFECTS OF SAFFRON AQUEOUS EXTRACT AND ITS MAIN CONSTITUENT, CROCIN, ON HEALTH-RELATED QUALITY OF LIFE, DEPRESSION, AND SEXUAL DESIRE INCORONARY ARTERY DISEASE PATIENTS: A DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(9), 0-0. SID. https://sid.ir/paper/293727/en

Vancouver: Copy

Abedimanesh Nasim, OSTADRAHIMI ALIREZA, Bathaie S.Zahra, ABEDIMANESH SAEED, MOTLAGH BEHROOZ, ASGHARI JAFARABADI MOHAMMAD, TABAN SADEGHI MOHAMMAD REZA. EFFECTS OF SAFFRON AQUEOUS EXTRACT AND ITS MAIN CONSTITUENT, CROCIN, ON HEALTH-RELATED QUALITY OF LIFE, DEPRESSION, AND SEXUAL DESIRE INCORONARY ARTERY DISEASE PATIENTS: A DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(9):0-0. Available from: https://sid.ir/paper/293727/en

IEEE: Copy

Nasim Abedimanesh, ALIREZA OSTADRAHIMI, S.Zahra Bathaie, SAEED ABEDIMANESH, BEHROOZ MOTLAGH, MOHAMMAD ASGHARI JAFARABADI, and MOHAMMAD REZA TABAN SADEGHI, “EFFECTS OF SAFFRON AQUEOUS EXTRACT AND ITS MAIN CONSTITUENT, CROCIN, ON HEALTH-RELATED QUALITY OF LIFE, DEPRESSION, AND SEXUAL DESIRE INCORONARY ARTERY DISEASE PATIENTS: A DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED CLINICAL TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 9, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293727/en

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