IDENTIFICATION OF THE COREGULATED MRNA AND LNCRNA FUNCTIONALPATHWAYS IN OVARIAN CANCER USING LNCRNAS2PATHWAYS BY LNCRNASBASED ON AN INTEGRATED NETWORK PROPAGATION

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QU LU YUN; JIANG HAI YANG; WANG JING; LI ZENG HUI; LI XIAO HONG; HOU JIAN QING

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Journal: Iranian Red Crescent Medical Journal Year:2018 | Volume:20 | Issue:5 Page(s): 0-0

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Title

IDENTIFICATION OF THE COREGULATED MRNA AND LNCRNA FUNCTIONALPATHWAYS IN OVARIAN CANCER USING LNCRNAS2PATHWAYS BY LNCRNASBASED ON AN INTEGRATED NETWORK PROPAGATION

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Keywords

LNCRNAS2PATHWAYS FUNCTIONAL

LONG NON-CODING

MESSENGER

NEOPLASM

OVARIAN

PATHWAY

RNA

Abstract

Background: OVARIAN Cancer is one of the most fatal female NEOPLASMs associated with high mortality. Finding of the new mechanismsinvolved in the development of OVARIAN cancer will help us to better diagnosis and effective treatment. Objectives: The current bioinformatics study aimed at investigating the relationship between MESSENGER RNA (mRNA) and longnon-coding RNA (lncRNA) in OVARIAN cancer through the LncRNAs2Pathways method. Methods: The genome-wide lncRNA andmRNAdata obtained from 185 OVARIAN cancer and healthy control samples originated fromMichigan Medical School were downloaded and pretreated from European bioinformatics institute (EMBL-EBI) database. The interactionsbetween miRNA and mRNA, and the intersections between lncRNA and miRNA were identified with starBase version 2. 0. Along non-coding RNA-mediated ceRNA network (LMCN) was constructed by integrating lncRNA-mRNA and lncRNA-mRNA intersections. Then, the lncRNAs were mapped to the network, and these lncRNAs were regarded as source nodes, and the random walk withrestart (RWR) algorithm was also applied to evaluate the effect of source nodes on protein-coding genes. Finally, the Kolmogorov-Smirnov-like statistics weighted by the propagation score was used to evaluate the enrichment value of each functional PATHWAY. Results: After preliminary screening, the gene expression profile including 12, 437 genes was obtained. The LMCN network including11 lncRNA and 367 mRNA were identified. A total of 11 differentially expressed lncRNAs between the normal and OVARIAN cancersamples by the LCMN network were identified. The LncRNAs2Pathways screened six functional PATHWAYs (P < 0. 05) coregulated bylncRNAs related to OVARIAN cancer. Conclusions: A total of six functional PATHWAYs related to lncRNA and mRNA interactions in OVARIAN cancer were identified. Thisfinding is beneficial for effective diagnosis of patients with OVARIAN cancer, and also provides a new insight into the treatment ofthis disease.

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APA: Copy

QU, LU YUN, JIANG, HAI YANG, WANG, JING, LI, ZENG HUI, LI, XIAO HONG, & HOU, JIAN QING. (2018). IDENTIFICATION OF THE COREGULATED MRNA AND LNCRNA FUNCTIONALPATHWAYS IN OVARIAN CANCER USING LNCRNAS2PATHWAYS BY LNCRNASBASED ON AN INTEGRATED NETWORK PROPAGATION. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(5), 0-0. SID. https://sid.ir/paper/293749/en

Vancouver: Copy

QU LU YUN, JIANG HAI YANG, WANG JING, LI ZENG HUI, LI XIAO HONG, HOU JIAN QING. IDENTIFICATION OF THE COREGULATED MRNA AND LNCRNA FUNCTIONALPATHWAYS IN OVARIAN CANCER USING LNCRNAS2PATHWAYS BY LNCRNASBASED ON AN INTEGRATED NETWORK PROPAGATION. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(5):0-0. Available from: https://sid.ir/paper/293749/en

IEEE: Copy

LU YUN QU, HAI YANG JIANG, JING WANG, ZENG HUI LI, XIAO HONG LI, and JIAN QING HOU, “IDENTIFICATION OF THE COREGULATED MRNA AND LNCRNA FUNCTIONALPATHWAYS IN OVARIAN CANCER USING LNCRNAS2PATHWAYS BY LNCRNASBASED ON AN INTEGRATED NETWORK PROPAGATION,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 5, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293749/en

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