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Title

EVALUATION OF HEMOCYTOMETER PARAMETERS AS POTENTIAL BIOMARKERS INBENIGN MULTINODULAR GOITER AND PAPILLARY THYROID CARCINOMA

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Abstract

 Background: Hemocytometer parameters can be important biomarkers for some types of cancers and diseases. There is a need toevaluate their biomarker potential in thyroid diseases. Objectives: The current study aimed at contributing to potential biomarker researches to diagnose PAPILLARY THYROID CARCINOMA(PTC) and benign multinodular GOITER (BMG), evaluate the role of these markers to determine the PTC characteristics and contributeto clarification of controversial issues. Methods: The study was designed as a retrospective observational study. The study included 389 patients who underwent totalthyroidectomy at private Sani Konukoglu hospital (Sanko University, School of Medicine, Gaziantep, Turkey) due to BMG or PTCdiagnosis from November 2011 to May 2017. The study subjects were divided into 3 groups. Groups 1, 2, and 3 were subjects with BMG, PTC, and the control, respectively. The comparisons were made among the groups in terms of hemocytometer parameters. In thegroup with the thyroid papillary carcinoma diagnosis, the relationship between the hemocytometer parameters and the bilateraltumor presence, single-sided multicentrite, and tumor diameter (size) were investigated. Results: Red cell distribution width (RDW) levels were 15. 50 2. 39, 15. 68 2. 16, and 12. 5 1. 51 in the BMG, PTC, and control groups, respectively. Mean PLATELET volumes (MPV) were 7. 97 1. 19, 8. 05 1. 20, and 7. 23 1. 39 in the BMG, PTC, and control groups, respectively. MPV and RDW values were significantly lower in group 3 compared with the groups 1 and 2 (P < 0. 0001). PLATELETcrit (PCT)values were 0. 22 0. 05, 0. 23 0. 06, and 0. 19 0. 05 in the BMG, PTC, and control groups, respectively. PCT was significantly lowerin the group 3 compared with the groups 1 and 2 (P = 0. 0001). In PTC group, no significant relationship was observed between anyof the examined hematological parameters in terms of multicentric and bilateral tumor presence. Conclusions: RDW, MPV, haemoglobin content, and PCT were significantly higher in the BMG and PTC groups. This increase wasnot specific for either of the 2 groups. No significant difference was found between any of the hemocytometer parameters andthe multicentricity and bilaterality of PTC. But, a possible correlation was observed between activated partial thromboplastin time(aPTT), hemoglobin content, and tumor size.

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    APA: Copy

    UYSAL, ERDAL, CEYLAN, SEYIT MEHMET, SEZGIN, EFE, BAKIR, HASAN, GURER, AHMET ORHAN, AKSOY, BASAR, & BASTEMIR, MEHMET. (2017). EVALUATION OF HEMOCYTOMETER PARAMETERS AS POTENTIAL BIOMARKERS INBENIGN MULTINODULAR GOITER AND PAPILLARY THYROID CARCINOMA. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(12), 0-0. SID. https://sid.ir/paper/293829/en

    Vancouver: Copy

    UYSAL ERDAL, CEYLAN SEYIT MEHMET, SEZGIN EFE, BAKIR HASAN, GURER AHMET ORHAN, AKSOY BASAR, BASTEMIR MEHMET. EVALUATION OF HEMOCYTOMETER PARAMETERS AS POTENTIAL BIOMARKERS INBENIGN MULTINODULAR GOITER AND PAPILLARY THYROID CARCINOMA. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(12):0-0. Available from: https://sid.ir/paper/293829/en

    IEEE: Copy

    ERDAL UYSAL, SEYIT MEHMET CEYLAN, EFE SEZGIN, HASAN BAKIR, AHMET ORHAN GURER, BASAR AKSOY, and MEHMET BASTEMIR, “EVALUATION OF HEMOCYTOMETER PARAMETERS AS POTENTIAL BIOMARKERS INBENIGN MULTINODULAR GOITER AND PAPILLARY THYROID CARCINOMA,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 12, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293829/en

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