Pain Relief in the Sickle-Cell Crisis: Intravenous Morphine Versus Ketorolac; A Double-Blind, Randomized Clinical Trial

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TALEBI DOLUEE MORTEZA; REZVANI KAKHKI BEHRANG; Heidarian Mir Hamid; Fatemi nayyeri Mahsa; Madani torbati Farideh; Hosseini Somayyehalsadat

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Red Crescent Medical Journal Year:2019 | Volume:21 | Issue:4 Page(s): 0-0

Download Full-Text

View:

285

Download:

940

Cites:

Information Journal Paper

Title

Pain Relief in the Sickle-Cell Crisis: Intravenous Morphine Versus Ketorolac; A Double-Blind, Randomized Clinical Trial

Author(s)

Keywords

Anemia

Congenital

Hemoglobinopathies

Ketorolac

Morphine

Pain

Sickle Cell

Vaso-Occlusive Crisis

Abstract

Background: Sickle Cell disease (SCD) is a Congenital hemoglobinopathy. A low Hb level and high hemoglobin-to-hematocrit ratio maylead to the Vaso-Occlusive Crisis in patients, for the management of which hyperbaric oxygen, hydration, and Pain relief therapy are proposed. Objectives: In this study, we sought to compare the effects of Morphine and Ketorolac on relieving Painful Sickle Cell crisis. Methods: In this double-blind, randomized clinical trial, we recruited 92 SCD patients who referred to the Emergency Department of a university-affiliated hospital, in Mashhad, Iran, from December 2016 to May 2017. The patients were randomly assigned to two groups of Ketorolac and Morphine injections for relieving Pain crisis according to the clinical conditions of the patients. Pain severity was measured by the visual analogue scale before and after the intervention. Data were analyzed using SPSS software. Results: A total of 92 SCD patients were evaluated, while, 19 (21%) were female and 73 (79%) were male, with the mean age of 20. 77 8. 6 years. At the pre-injection phase, the mean Pain scores were 9. 1 0. 4 and 9. 1 0. 7 in the Ketorolac and Morphine groups, respectively. After the intervention, the mean Pain scores were 3. 7 1. 2 and 4. 9 2. 1 in the Ketorolac and Morphine groups, respectively. A significant association was found between the Pain score after drug injection and the administered drug (P = 0. 006). Conclusions: The management of Pain crisis with Ketorolac injection yielded the same results as the Morphine injection in SCD patients. However, Ketorolac was found to be associated with fewer side effects than Morphine; thus, it can be beneficial for managing SCD patients suffering Pain crisis.

Cites

No record.

References

Cite

APA: Copy

TALEBI DOLUEE, MORTEZA, REZVANI KAKHKI, BEHRANG, Heidarian Mir, Hamid, Fatemi nayyeri, Mahsa, Madani torbati, Farideh, & Hosseini, Somayyehalsadat. (2019). Pain Relief in the Sickle-Cell Crisis: Intravenous Morphine Versus Ketorolac; A Double-Blind, Randomized Clinical Trial. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 21(4), 0-0. SID. https://sid.ir/paper/293886/en

Vancouver: Copy

TALEBI DOLUEE MORTEZA, REZVANI KAKHKI BEHRANG, Heidarian Mir Hamid, Fatemi nayyeri Mahsa, Madani torbati Farideh, Hosseini Somayyehalsadat. Pain Relief in the Sickle-Cell Crisis: Intravenous Morphine Versus Ketorolac; A Double-Blind, Randomized Clinical Trial. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2019;21(4):0-0. Available from: https://sid.ir/paper/293886/en

IEEE: Copy

MORTEZA TALEBI DOLUEE, BEHRANG REZVANI KAKHKI, Hamid Heidarian Mir, Mahsa Fatemi nayyeri, Farideh Madani torbati, and Somayyehalsadat Hosseini, “Pain Relief in the Sickle-Cell Crisis: Intravenous Morphine Versus Ketorolac; A Double-Blind, Randomized Clinical Trial,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 21, no. 4, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/293886/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops