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Title

Increased Expression of miR-1 in Fast-Twitch Skeletal Muscle in Response to Resistance Exercise

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Abstract

 Background: The response of microRNA (miR-1), upstream regulators (Myogenic Differentiation 1 (MyoD1) and Myocyte Enhancer Factor 2C (Mef2C)), and a downstream target (Histone Deacetylase 4 (Hdac4)) to an acute bout of Resistance Exercise (RE) in Extensor Digitorum Longus (EDL) and soleus muscles has remained elusive. Objectives: In this experimental study, we investigated the effect of an acute bout of RE on the Expression of miR-1, MyoD1, Mef2C, and Hdac4 Genes in the slow and fast-twitch muscle of Rats. Methods: The current study was conducted at Tarbiat Modares University, Tehran, Iran, in 2017. Fifteen male Wistar Rats were randomly divided into two groups, control (n = 5) and RE (n = 10). The RE protocol consisted of four sets of five repetitions of climbing a ladder with weights attached to the tails of Rats. The soleus and EDL muscles of Rats were collected at 3 h (n = 5) and 6 h (n = 5) post-RE. The real-time Polymerase Chain Reaction was used to measure the levels of miR-1, MyoD1, Mef2C, and Hdac4 mRNA Expression. Results: The miR-1 Expression in EDL muscle was significantly lower at 3 h and 6 h post-exercise in the RE group than in the control group (P< 0. 01). The miR-1 Expression in soleus muscle was significantly lower at 3 h post-exercise in the RE group than in the control group (P < 0. 007) but it was significantly higher at 6 h post-exercise (P < 0. 036). The Expression of MyoD1, Mef2C, and Hdac4 Genes in the EDL muscle was higher in the RE group than in the control group (P < 0. 01). The Expression of these Genes in response to RE had more fluctuations in soleus muscle. Conclusions: It can be concluded that miR-1 Expression in extensor digitorum longus and soleus muscles of Rats responds to Resistance Exercise in different manners and this coincides with a change in upstream regulators and downstream target.

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    APA: Copy

    FATHI, MOHAMMAD, GHARAKHANLOU, REZA, SOLEIMANI, MASOUD, & RAJABI, HAMID. (2019). Increased Expression of miR-1 in Fast-Twitch Skeletal Muscle in Response to Resistance Exercise. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 21(4), 0-0. SID. https://sid.ir/paper/293887/en

    Vancouver: Copy

    FATHI MOHAMMAD, GHARAKHANLOU REZA, SOLEIMANI MASOUD, RAJABI HAMID. Increased Expression of miR-1 in Fast-Twitch Skeletal Muscle in Response to Resistance Exercise. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2019;21(4):0-0. Available from: https://sid.ir/paper/293887/en

    IEEE: Copy

    MOHAMMAD FATHI, REZA GHARAKHANLOU, MASOUD SOLEIMANI, and HAMID RAJABI, “Increased Expression of miR-1 in Fast-Twitch Skeletal Muscle in Response to Resistance Exercise,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 21, no. 4, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/293887/en

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