HISTOPATHOLOGICAL STUDY OF TCDD BY ISOLATED RAT LIVER PERFUSION SYSTEM

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KARAMI M.; GHAZI KHANSARI M.; REZAYAT M.; MINAEI ZANGI M.B.; ABDOLLAHI M.; SABZEVARI O.

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Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2001 | Volume:15 | Issue:1 Page(s): 55-59

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Title

HISTOPATHOLOGICAL STUDY OF TCDD BY ISOLATED RAT LIVER PERFUSION SYSTEM

Author(s)

Keywords

TCDD

LIVER PERFUSION

KREBS-HENSELEIT BUFFER

HISTOPATHOLOGICAL

NECROSIS.

Abstract

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a by-product of the trichlorophenol (herbicide) production and is also produced through a variety of combustion processes. It appears that TCDD is a ubiquitous chemical, particularly in industrialised countries, and the liver is the target organ of its toxicity. The prominent hepatotoxic effect of TCDD is progressive centrilobular NECROSIS. The isolated rat LIVER PERFUSION system approaches the normal physiology of the liver and is ideal for studying biochemical alterations of the liver since hepatocytes are easily exposed to various concentrations of chemicals with minimum neural-hormonal effects. In this study, the liver was perfused with KREBS-HENSELEIT BUFFER containing different concentrations of TCDD (0.3, 3, 20 and 30 mg/L). During the perfusion many factors including gross liver appearance, bile formation, and aminotransferase activities were assessed as indicators of liver viability. Consequently, sections of liver tissue were examined for any HISTOPATHOLOGICAL changes. The results showed that HISTOPATHOLOGICAL changes in liver tissues were related in a dose-dependent manner to TCDD concentrations. In this instance doses of 20 and 30 mg/L caused a significant (p<0.05) HISTOPATHOLOGICAL change in liver sections. Liver NECROSIS.and hemorrhage were also increased significantly in a dose-dependent manner.

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APA: Copy

KARAMI, M., GHAZI KHANSARI, M., REZAYAT, M., MINAEI ZANGI, M.B., ABDOLLAHI, M., & SABZEVARI, O.. (2001). HISTOPATHOLOGICAL STUDY OF TCDD BY ISOLATED RAT LIVER PERFUSION SYSTEM. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 15(1), 55-59. SID. https://sid.ir/paper/293902/en

Vancouver: Copy

KARAMI M., GHAZI KHANSARI M., REZAYAT M., MINAEI ZANGI M.B., ABDOLLAHI M., SABZEVARI O.. HISTOPATHOLOGICAL STUDY OF TCDD BY ISOLATED RAT LIVER PERFUSION SYSTEM. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2001;15(1):55-59. Available from: https://sid.ir/paper/293902/en

IEEE: Copy

M. KARAMI, M. GHAZI KHANSARI, M. REZAYAT, M.B. MINAEI ZANGI, M. ABDOLLAHI, and O. SABZEVARI, “HISTOPATHOLOGICAL STUDY OF TCDD BY ISOLATED RAT LIVER PERFUSION SYSTEM,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 15, no. 1, pp. 55–59, 2001, [Online]. Available: https://sid.ir/paper/293902/en

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