THE DILEMMA OF HEMODYNAMIC INSTABILITY DURING INDUCTION OF ANESTHESIA: CAN MIDAZOLAM SERVE AS A SUITABLE SUBSTITUTE FOR THIOPENTONE?

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HOSSEINKHAN ZAHED; SABERI H.; BITARAF M.A.

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Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2003 | Volume:16 | Issue:4 Page(s): 183-187

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Title

THE DILEMMA OF HEMODYNAMIC INSTABILITY DURING INDUCTION OF ANESTHESIA: CAN MIDAZOLAM SERVE AS A SUITABLE SUBSTITUTE FOR THIOPENTONE?

Author(s)

HOSSEINKHAN ZAHED | SABERI H. | BITARAF M.A. | Issue Writer Certificate

Keywords

HEMODYNAMIC INSTABILITY

INDUCTION OF ANESTHESIA

MIDAZOLAM

THIOPENTAL SODIUM

Abstract

Both MIDAZOLAM and THIOPENTAL SODIUM are being used as induction agents and for maintenance of anesthesia. In contrast to other benzodiazepines such as diazepam, MIDAZOLAM has a rapid onset of action and fast distribution and causes few cardiovascular or respiratory effects. Being water soluble, MIDAZOLAM is also associated with a low incidence of venous irritation. The purpose of this study was to see whether MIDAZOLAM is a suitable substitute for THIOPENTAL SODIUM as an induction agent. To compare the hemodynamic changes associated with MIDAZOLAM and THIOPENTAL SODIUM as induction agents, this study was conducted in two groups each comprising of 30 patients. No significant hemodynamic changes regarding heart rate and blood pressure could be noticed in the two groups (p<0.05). All patients in the MIDAZOLAM group exhibited anterograde amnesia but in the thiopental group, 20% of the patients had recall for operative events one hour after completion of surgery. To arrive at more conclusive results, preferably multi-center studies involving large numbers of cases are recommended.

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APA: Copy

HOSSEINKHAN, ZAHED, SABERI, H., & BITARAF, M.A.. (2003). THE DILEMMA OF HEMODYNAMIC INSTABILITY DURING INDUCTION OF ANESTHESIA: CAN MIDAZOLAM SERVE AS A SUITABLE SUBSTITUTE FOR THIOPENTONE?. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 16(4), 183-187. SID. https://sid.ir/paper/294037/en

Vancouver: Copy

HOSSEINKHAN ZAHED, SABERI H., BITARAF M.A.. THE DILEMMA OF HEMODYNAMIC INSTABILITY DURING INDUCTION OF ANESTHESIA: CAN MIDAZOLAM SERVE AS A SUITABLE SUBSTITUTE FOR THIOPENTONE?. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2003;16(4):183-187. Available from: https://sid.ir/paper/294037/en

IEEE: Copy

ZAHED HOSSEINKHAN, H. SABERI, and M.A. BITARAF, “THE DILEMMA OF HEMODYNAMIC INSTABILITY DURING INDUCTION OF ANESTHESIA: CAN MIDAZOLAM SERVE AS A SUITABLE SUBSTITUTE FOR THIOPENTONE?,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 16, no. 4, pp. 183–187, 2003, [Online]. Available: https://sid.ir/paper/294037/en

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