CYTOTOXIC ACTIVITY OF THYMUS VULGARIS, ACHILLEA MILLEFOLIUM AND THUJA ORIENTALISON DIFFERENT GROWING CELL LINES

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AMIR GHOFRAN Z.; KARIMI M.H.

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Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2001 | Volume:15 | Issue:3 Page(s): 149-154

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Title

CYTOTOXIC ACTIVITY OF THYMUS VULGARIS, ACHILLEA MILLEFOLIUM AND THUJA ORIENTALISON DIFFERENT GROWING CELL LINES

Author(s)

AMIR GHOFRAN Z. | KARIMI M.H. | Issue Writer Certificate

Keywords

CYTOTOXIC ACTIVITY

THYMUS VULGARIS

ACHILLEA MILLEFOLIUM

THUJA ORIENTALIS

MTT ASSAY

Abstract

The CYTOTOXIC ACTIVITY of ethanolic extracts of THYMUS VULGARIS, THUJA ORIENTALIS and ACHILLEA MILLEFOLIUM was investigated on various growing tumor cell lines. MTT colorimetric assay was used for measuring the inhibition of cell proliferation. All of the three extracts showed a relatively dose-dependent inhibition of proliferation of human breast cancer (SK-Br-3, MDA-MB-435) and leukemia (U937 and K562) cell lines. The most sensitive cells to the effect of THUJA ORIENTALIS and ACHILLEA MILLEFOLIUM extracts were K562 and SK-Br-3and to THYMUS VULGARIS were U937 and MDA(50% inhibition at 10 µg/mL). Hela cell line was less sensitive than other tumor cell lines (% inhibition range -10 to 46). Despite this potential cytolytic activity against tumor cell lines, low concentrations of the extracts showed stimulatory effects on the growth of Vero, a non-malignant cell line. Proliferation of these cells was increased by 10 to 100 µg/mL of ACHILLEA MILLEFOLIUM and THYMUS VULGARIS (% inhibition range-48.8to -6.25) and suppressed by a concentrationof 400 µg/mL (%inhibition 6.25 and 27.6, respectively). Various concentrations of THUJA ORIENTALIS showed stimulatory effects on this cell line (% inhibition range - 34.00to -21.4).Study of the effect of two low and high concentrations of the extracts on mitogen-induced human lymphocytes resulted in a slight increase at 50 µg/mL (Stimulation index, SI range 1.19 to 1.37, p<0.01).In conclusion, although the extracts showed strong cytotoxicity for tumor cell lines,theproliferativelymphocytesandthenon-malignantcelllineusedin this study were clearly less sensitive.

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APA: Copy

AMIR GHOFRAN, Z., & KARIMI, M.H.. (2001). CYTOTOXIC ACTIVITY OF THYMUS VULGARIS, ACHILLEA MILLEFOLIUM AND THUJA ORIENTALISON DIFFERENT GROWING CELL LINES. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 15(3), 149-154. SID. https://sid.ir/paper/294046/en

Vancouver: Copy

AMIR GHOFRAN Z., KARIMI M.H.. CYTOTOXIC ACTIVITY OF THYMUS VULGARIS, ACHILLEA MILLEFOLIUM AND THUJA ORIENTALISON DIFFERENT GROWING CELL LINES. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2001;15(3):149-154. Available from: https://sid.ir/paper/294046/en

IEEE: Copy

Z. AMIR GHOFRAN, and M.H. KARIMI, “CYTOTOXIC ACTIVITY OF THYMUS VULGARIS, ACHILLEA MILLEFOLIUM AND THUJA ORIENTALISON DIFFERENT GROWING CELL LINES,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 15, no. 3, pp. 149–154, 2001, [Online]. Available: https://sid.ir/paper/294046/en

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