EFFECT OF CARBAMAZEPINE ON THE SPONTANEOUS BEATING OF ISOLATED GUINEA PIG ATRIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

POUSTI A.; BAKHTIARI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2001 | Volume:15 | Issue:3 Page(s): 165-169

Download Full-Text

View:

231

Download:

Cites:

Information Journal Paper

Title

EFFECT OF CARBAMAZEPINE ON THE SPONTANEOUS BEATING OF ISOLATED GUINEA PIG ATRIA

Author(s)

POUSTI A. | BAKHTIARI S. | Issue Writer Certificate

Keywords

CARBAMAZEPINE

ISOLATED ATRIA. THEOPHYLLINE

ADENOSINE RECEPTORS

Abstract

CARBAMAZEPINE, a drug effective in pain, seizure, and affective disorders, was studied for its effects and toxicity on spontaneously beating isolated guinea pig atria. CARBAMAZEPINE (20-30 µg/mL) has a negative chronotropic effect on artria, without any significant effect on contractile force. The most significant effect (12.5%) was seen with 30 µg/mL of CARBAMAZEPINE on atria. With higher doses (>30 µg/mL) CARBAMAZEPINE produced toxic effects which resulted in atrial standstill. Pretreament of atria with theophylline (5-50 µg/mL) prevented the negative chronotropic effect of CARBAMAZEPINE (30 µg/mL). Three dose ratios of CARBAMAZEPINE (1.33,2,2.33) in the presence of three different doses of theophylline (30, 50 and 60 µg/mL) were obtained. These results suggest that the negative chronotropic effect of CARBAMAZEPINE and its toxicity may be due to its action as an agonist on adenosine Al receptors and as an antagonist on A2 receptors of the atria. Moreover, using adenosine antagonists such as theophylline may overcome the toxic effect of CARBAMAZEPINE on the heart. This may explain the reason for the interaction between CARBAMAZEPINE and theophylline in clinical settings.

Cites

No record.

References

No record.

Cite

APA: Copy

POUSTI, A., & BAKHTIARI, S.. (2001). EFFECT OF CARBAMAZEPINE ON THE SPONTANEOUS BEATING OF ISOLATED GUINEA PIG ATRIA. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 15(3), 165-169. SID. https://sid.ir/paper/294047/en

Vancouver: Copy

POUSTI A., BAKHTIARI S.. EFFECT OF CARBAMAZEPINE ON THE SPONTANEOUS BEATING OF ISOLATED GUINEA PIG ATRIA. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2001;15(3):165-169. Available from: https://sid.ir/paper/294047/en

IEEE: Copy

A. POUSTI, and S. BAKHTIARI, “EFFECT OF CARBAMAZEPINE ON THE SPONTANEOUS BEATING OF ISOLATED GUINEA PIG ATRIA,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 15, no. 3, pp. 165–169, 2001, [Online]. Available: https://sid.ir/paper/294047/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops