PRODUCTION OF PROSTATE-SPECIFIC ANTIGEN (PSA) BY A BREAST CANCER CELL LINE, SK-BR-3

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KAMALI SARVESTANI E.; GHADERI A.; GHARESIFARD B.

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Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2002 | Volume:16 | Issue:1 Page(s): 41-46

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Information Journal Paper

Title

PRODUCTION OF PROSTATE-SPECIFIC ANTIGEN (PSA) BY A BREAST CANCER CELL LINE, SK-BR-3

Author(s)

KAMALI SARVESTANI E. | GHADERI A. | GHARESIFARD B. | Issue Writer Certificate

Keywords

PSA

C-ERBB-2

PROGESTERONE RECEPTOR

BREAST CANCER

SK-BR-3

Abstract

PSA is a 33-KDa serine protease that is produced predominantly by prostate epithelium. However, it has been shown that about 30-40% of female breast tumors produce PSA and its production is associated with the presence of estrogen and PROGESTERONE RECEPTORs. We have now developed a new tissue culture system to study PSA production in BREAST CANCER and its association with prognostic factors such as PROGESTERONE RECEPTOR andc-erbB-2. For this purpose we investigated the ability of PSA production in five different cell lines, including two BREAST CANCER cell lines, SK-BR-3 and MDA-MB-453.The PSA in tissue culture supernatant and cytoplasm of the SK-BR-3 cell line was detected by western blotting and immunoperoxidase, respectively. Furthermore, we found lower expression of C-ERBB-2 in SK-BR-3 than non-PSA producer BREAST CANCER cell line, MDA-MB- 453. PROGESTERONE RECEPTOR was expressed by both PSA-positive and –negative cell lines and only the intensity of staining and the number of positive cells in Sk- Br-3 population was higher than MDA-MB-453.According to our findings PSA can be considered as a good prognostic factor in BREAST CANCER and we suggest that these two cell lines are a good in vitro model to study the relationship of different BREAST CANCER prognostic factors and their regulations.

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APA: Copy

KAMALI SARVESTANI, E., GHADERI, A., & GHARESIFARD, B.. (2002). PRODUCTION OF PROSTATE-SPECIFIC ANTIGEN (PSA) BY A BREAST CANCER CELL LINE, SK-BR-3. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 16(1), 41-46. SID. https://sid.ir/paper/294066/en

Vancouver: Copy

KAMALI SARVESTANI E., GHADERI A., GHARESIFARD B.. PRODUCTION OF PROSTATE-SPECIFIC ANTIGEN (PSA) BY A BREAST CANCER CELL LINE, SK-BR-3. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2002;16(1):41-46. Available from: https://sid.ir/paper/294066/en

IEEE: Copy

E. KAMALI SARVESTANI, A. GHADERI, and B. GHARESIFARD, “PRODUCTION OF PROSTATE-SPECIFIC ANTIGEN (PSA) BY A BREAST CANCER CELL LINE, SK-BR-3,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 16, no. 1, pp. 41–46, 2002, [Online]. Available: https://sid.ir/paper/294066/en

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