ANTINOCICEPTIVE EFFECT OF ELAEAGNUS ANGUSTIFOLIA FRUIT IN MICE

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HOSSEINZADEH HOSSEIN; TAHERI M.R.

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Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2000 | Volume:14 | Issue:1 Page(s): 77-81

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Information Journal Paper

Title

ANTINOCICEPTIVE EFFECT OF ELAEAGNUS ANGUSTIFOLIA FRUIT IN MICE

Author(s)

HOSSEINZADEH HOSSEIN | TAHERI M.R. | Issue Writer Certificate

Keywords

ELAEAGNUS ANGUSTIFOLIA

ANTINOCICEPTIVE ACTIVITY

MUSCLE RELAXATION

HOT-PLATE

TAIL-FLICK

TRACTIONTEST

MEDICINAL PLANTS

Abstract

The antinociceptive effect of ELAEAGNUS ANGUSTIFOLIA fruits was studied in mice. The antinociceptive effect of ethanolic and boiling water extracts was studied using two thermal stimuli, the HOT-PLATE and TAIL-FLICK tests. The intraperitoneal and oral administration of the ethanolic extract of seed (1.75-7.00 g/kg), but not pericarp and medulla had significant ANTINOCICEPTIVE ACTIVITY in the HOT-PLATE test. Naloxone pretreatment did not inhibit the ANTINOCICEPTIVE ACTIVITY of the extract. The aqueous extract of different parts of the fruit (seed, medulla and pericarp) had ANTINOCICEPTIVE ACTIVITY in this test. The ethanolic extract of the seed had no antinociceptive effect in the TAIL-FLICK test and its effect was not abolished by naloxone. A 70% failure rate in the traction test (a MUSCLE RELAXATION test) was induced by ethanolic extract of the seed (3.5g/kg), compared withthe75%induced by the reference drug diazepam (2.5mg/kg). It is concluded that the antinociceptive effect of E. angustifolia may be mediated by a supraspinal effect and MUSCLE RELAXATION activity.

Cites

EFFECT OF ORAL (SYSTEMIC) ELAEAGNUS ANGUSTIFOLIA L. FRUIT ON STIMULATED GASTRIC ACID SECRETION IN UNCONSCIOUS RAT AND ON BASAL ACID SECRETION IN CONSCIOUS RAT

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Cite

APA: Copy

HOSSEINZADEH, HOSSEIN, & TAHERI, M.R.. (2000). ANTINOCICEPTIVE EFFECT OF ELAEAGNUS ANGUSTIFOLIA FRUIT IN MICE. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 14(1), 77-81. SID. https://sid.ir/paper/294293/en

Vancouver: Copy

HOSSEINZADEH HOSSEIN, TAHERI M.R.. ANTINOCICEPTIVE EFFECT OF ELAEAGNUS ANGUSTIFOLIA FRUIT IN MICE. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2000;14(1):77-81. Available from: https://sid.ir/paper/294293/en

IEEE: Copy

HOSSEIN HOSSEINZADEH, and M.R. TAHERI, “ANTINOCICEPTIVE EFFECT OF ELAEAGNUS ANGUSTIFOLIA FRUIT IN MICE,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 14, no. 1, pp. 77–81, 2000, [Online]. Available: https://sid.ir/paper/294293/en

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