EFFECTS OF DOPAMINERECEPTOR AGONISTS AND ANTAGONISTS ON BACLOFEN-INDUCED ANTINOCICEPTION IN FORMALIN TEST

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ZARINDAST M.R.; HASHEMI B.; TOLOUI V.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2000 | Volume:14 | Issue:1 Page(s): 69-75

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Title

EFFECTS OF DOPAMINERECEPTOR AGONISTS AND ANTAGONISTS ON BACLOFEN-INDUCED ANTINOCICEPTION IN FORMALIN TEST

Author(s)

ZARINDAST M.R. | HASHEMI B. | TOLOUI V. | Issue Writer Certificate

Keywords

BACLOFEN

DOPAMINE AGONISTS

DOPAMINE ANTAGONISTS

FORMALIN TEST

MICE

Abstract

In this study, the influence of dopamine receptor agonists and antagonists on antinociception induced by BACLOFEN has been examined in the FORMALIN TEST. The OABA-B agonist BACLOFEN induced antinociception in bothphases of the FORMALIN TEST in MICE. The dopamine receptor agonists SKF 38393 and quinpirole also induced antinociception in both phases of the test. SKF 38393 but not quinpirole potentiated the response to BACLOFEN in the first phase of the test. The dopamine receptor antagonists SCH 23390 and sulpiride increased the response to BACLOFEN in the first phase. Both drugs induced antinociception in the first phase of the FORMALIN TEST. However, low doses of sulpiride increased the pain response in the second phase. The peripheral dopamine receptor antagonist domperidone did not alter the effect of the test by itself. Dopamine receptor mechanisms appear to interact with BACLOFEN-induced antinociception.

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APA: Copy

ZARINDAST, M.R., HASHEMI, B., & TOLOUI, V.. (2000). EFFECTS OF DOPAMINERECEPTOR AGONISTS AND ANTAGONISTS ON BACLOFEN-INDUCED ANTINOCICEPTION IN FORMALIN TEST. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 14(1), 69-75. SID. https://sid.ir/paper/294294/en

Vancouver: Copy

ZARINDAST M.R., HASHEMI B., TOLOUI V.. EFFECTS OF DOPAMINERECEPTOR AGONISTS AND ANTAGONISTS ON BACLOFEN-INDUCED ANTINOCICEPTION IN FORMALIN TEST. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2000;14(1):69-75. Available from: https://sid.ir/paper/294294/en

IEEE: Copy

M.R. ZARINDAST, B. HASHEMI, and V. TOLOUI, “EFFECTS OF DOPAMINERECEPTOR AGONISTS AND ANTAGONISTS ON BACLOFEN-INDUCED ANTINOCICEPTION IN FORMALIN TEST,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 14, no. 1, pp. 69–75, 2000, [Online]. Available: https://sid.ir/paper/294294/en

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