THE SPECTRUM OF β- THALASSEMIA MUTATIONSIN IRAN

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MERAT A.; HAGHSHENAS M.

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Journal Paper

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Journal: Medical Journal of The Islamic Republic of Iran Year:2000 | Volume:14 | Issue:1 Page(s): 103-106

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Title

THE SPECTRUM OF β- THALASSEMIA MUTATIONSIN IRAN

Author(s)

MERAT A. | HAGHSHENAS M. | Issue Writer Certificate

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Abstract

Thalassemias are the world's most widespread genetic disorder known in m,m.22According to a WHO report,25 thalassemia carriers are estimated to exceed 100 million persons Md some 100 thousMd affected babies are born each year. The incidence, prevalence and clinical forms of thalassemia vary in different parts of the world. However, the most common clinical forms of thalassemia vary in different parts of the world. However, the most common clinical presentation observed is thalassemia trait or the heterozygous state of either beta or alpha thalassemia. Betathalassemia is highest in prevalence in the Mediterrcmean area and parts of Africa Md Asia, whereas alpha-thalassemia is highest among Asian populations in which 3.5% of the people are alpha-thalassem iacarriers.4 Thalassem ias produce a massi ve public health problem in mMY countries but occur at a very high frequency in a broad belt stretching from the Mediterranean basin through the Middle East, India, Burma and Southern Asia.22Thalassemia is a hereditary hemolytic disease accompanied by hypochromic microcytic anemia. It is inherited as M autosomal recessive trait Md encompasses a broad range of clinical manifestations. In all thalassemias, there is a reduction in the rate of synthesis of the globin chains that form normal hemoglobins. Thus, if there is a reduction in alpha chain synthesis the condition is an alphathalassemja. If the reduction is in beta chain synthesis the condition is a beta thalassemia. When the mutation leads to a complete lack of the alpha or beta chain the thalassemia is classified as alpha-0 or beta. Orespectively. If there is reduced alpha or beta chain synthesis they are called alpha+ or beta+ thalassemias.

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APA: Copy

MERAT, A., & HAGHSHENAS, M.. (2000). THE SPECTRUM OF β- THALASSEMIA MUTATIONSIN IRAN. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 14(1), 103-106. SID. https://sid.ir/paper/294304/en

Vancouver: Copy

MERAT A., HAGHSHENAS M.. THE SPECTRUM OF β- THALASSEMIA MUTATIONSIN IRAN. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2000;14(1):103-106. Available from: https://sid.ir/paper/294304/en

IEEE: Copy

A. MERAT, and M. HAGHSHENAS, “THE SPECTRUM OF β- THALASSEMIA MUTATIONSIN IRAN,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 14, no. 1, pp. 103–106, 2000, [Online]. Available: https://sid.ir/paper/294304/en

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