REDUCTION IN ISCHEMIC BRAIN INJURY FOLLOWING THE ADMINISTRATION OF PENTOXIFYLLINE AFTER TRANSIENT GLOBAL ISCHEMIA/ REPERFUSION IN A RAT MODEL

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NADIA SHARIFI ZAHRA; MOVASSAGHI SHABNAM; MOHAMADZADEH FARZANEH; SOLEIMANI ASL SARA; POURHEYDAR BAGHER; MEHDIZADEH MEHDI

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Journal: Medical Journal of The Islamic Republic of Iran Year:2015 | Volume:29 | Issue:1 Page(s): 0-0

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Title

REDUCTION IN ISCHEMIC BRAIN INJURY FOLLOWING THE ADMINISTRATION OF PENTOXIFYLLINE AFTER TRANSIENT GLOBAL ISCHEMIA/ REPERFUSION IN A RAT MODEL

Author(s)

Keywords

CEREBRAL ISCHEMIA

REPERFUSION

PENTOXIFYLLINE

HIPPOCAMPUS

Abstract

Background: It is well known that the HIPPOCAMPUS, the CA1 Pyramidal cells in particular, is selectively vulnerable during global CEREBRAL ISCHEMIA. Recently, it is observed that PENTOXIFYLLINE has a neuroprotective effect. This study explored the pharmacological relationship between ischemiainduced cell death of the HIPPOCAMPUS and the efficacy of a vasodilator agent (pentoxifylline) in the prevention of delayed neuronal death.Methods: This experimental study was performed on 4 groups: control, ischemia, experimental (200mg/kg PENTOXIFYLLINE injection one hour prior to and one hour following ischemia) and vehicle (normal saline). Transient global ischemia was induced by bilateral common carotid arteries occlusion.To investigate the apoptotic bodies and caspase-3 activities as a central role in the execution phase of apoptosis, the brains were prepared for the TUNEL technique.Results: PENTOXIFYLLINE administration limited apoptosis and caspase-3 activities in rats’ hippocampi.Our data showed no significant difference between the number of apoptotic bodies in the CA1 region of the HIPPOCAMPUS in the control and PENTOXIFYLLINE -treated groups (p=0.994). The results of one- way ANOVA revealed that that ischemia significantly increased caspase-3 levels in the HIPPOCAMPUS (p<0.05); however, the level of caspase-3 in PENTOXIFYLLINE -treated rats was less than the ischemic group.Conclusion: These results suggest that the neuroprotective effect of PENTOXIFYLLINE (200mg/kg) may be accompanied by a reduction in ischemic damage within the CA1 region of the HIPPOCAMPUS in rats subjected to transient global CEREBRAL ISCHEMIA.

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APA: Copy

NADIA SHARIFI, ZAHRA, MOVASSAGHI, SHABNAM, MOHAMADZADEH, FARZANEH, SOLEIMANI ASL, SARA, POURHEYDAR, BAGHER, & MEHDIZADEH, MEHDI. (2015). REDUCTION IN ISCHEMIC BRAIN INJURY FOLLOWING THE ADMINISTRATION OF PENTOXIFYLLINE AFTER TRANSIENT GLOBAL ISCHEMIA/ REPERFUSION IN A RAT MODEL. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 29(1), 0-0. SID. https://sid.ir/paper/294667/en

Vancouver: Copy

NADIA SHARIFI ZAHRA, MOVASSAGHI SHABNAM, MOHAMADZADEH FARZANEH, SOLEIMANI ASL SARA, POURHEYDAR BAGHER, MEHDIZADEH MEHDI. REDUCTION IN ISCHEMIC BRAIN INJURY FOLLOWING THE ADMINISTRATION OF PENTOXIFYLLINE AFTER TRANSIENT GLOBAL ISCHEMIA/ REPERFUSION IN A RAT MODEL. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2015;29(1):0-0. Available from: https://sid.ir/paper/294667/en

IEEE: Copy

ZAHRA NADIA SHARIFI, SHABNAM MOVASSAGHI, FARZANEH MOHAMADZADEH, SARA SOLEIMANI ASL, BAGHER POURHEYDAR, and MEHDI MEHDIZADEH, “REDUCTION IN ISCHEMIC BRAIN INJURY FOLLOWING THE ADMINISTRATION OF PENTOXIFYLLINE AFTER TRANSIENT GLOBAL ISCHEMIA/ REPERFUSION IN A RAT MODEL,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 29, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/294667/en

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