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Title

PLASMA OXYSTEROL LEVEL IN PATIENTS WITH CORONARY ARTERY STENOSIS AND ITS CHANGES IN RESPONSE TO THE TREATMENT WITH ATORVASTATIN

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Abstract

 Background: Considering the increasing incidence of coronary artery stenosis and its related complications, the importance of its etiology and inconsistent reports we aimed to determine the relationship between oxysterol, serum levels and severity of coronary atherosclerosis and effect of statins on oxysterol.Methods: A total of 85 patients referred to Taleghani Hospital, Tehran, Iran during 2011-2012 with coronary artery stenosis more than 75%, as determined by angiography, participated in the current study. Their demographic information and history of smoking and taking ATORVASTATIN was carefully recorded. Two milliliters of venous blood was obtained from each patient. The serum oxysterol level of samples was measured using the enzyme-linked immunosorbent assay (ELISA) method. Statistical analysis was performed using SPSS v.19.Results: Eighty five patients completed the study. Mean age of patients was 64.4 years; 51 (60%) were male; 55 (68%) had acute coronary syndrome and 30 (32%) had chronic stable angina.Mean±SD of plasma level of oxysterol was 24.8±0.2 pmol/ml. The normal range of oxysterol level was 13pmol/ml. Mean±SD of plasma oxysterol level in patients under statin therapy was 24.4±2.1 pmol/ml. In patients without receiving statins, plasma oxysterol level was 26.38±1.6pmol/ml.Conclusion: Findings of the present study indicated significant correlation between serum oxysterol and severity of coronary artery stenosis. It also demonstrated that receiving ATORVASTATIN is associated with significant reduction of plasma oxysterol level.

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    APA: Copy

    HAMZEH PORDAL, AMIR, HAJMIRESMAIL, SEYED JAVAD, ASSADPOOR PIRANFAR, MOHAMMAD, HEDAYATI, MEHDI, & AJAMI, MARJAN. (2015). PLASMA OXYSTEROL LEVEL IN PATIENTS WITH CORONARY ARTERY STENOSIS AND ITS CHANGES IN RESPONSE TO THE TREATMENT WITH ATORVASTATIN. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 29(1), 0-0. SID. https://sid.ir/paper/294673/en

    Vancouver: Copy

    HAMZEH PORDAL AMIR, HAJMIRESMAIL SEYED JAVAD, ASSADPOOR PIRANFAR MOHAMMAD, HEDAYATI MEHDI, AJAMI MARJAN. PLASMA OXYSTEROL LEVEL IN PATIENTS WITH CORONARY ARTERY STENOSIS AND ITS CHANGES IN RESPONSE TO THE TREATMENT WITH ATORVASTATIN. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2015;29(1):0-0. Available from: https://sid.ir/paper/294673/en

    IEEE: Copy

    AMIR HAMZEH PORDAL, SEYED JAVAD HAJMIRESMAIL, MOHAMMAD ASSADPOOR PIRANFAR, MEHDI HEDAYATI, and MARJAN AJAMI, “PLASMA OXYSTEROL LEVEL IN PATIENTS WITH CORONARY ARTERY STENOSIS AND ITS CHANGES IN RESPONSE TO THE TREATMENT WITH ATORVASTATIN,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 29, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/294673/en

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